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cART in vertically HIV-infected children treated since infancy

Purpose of the study

To evaluate cART efficacy, number of regimens and resistance development in vertically HIV-infected children treated since infancy.

Methods

27 children vertically infected with HIV. In 6/27 children treatment was started before HAART era. In 11/27 patients cART regimen was based on baseline resistance reports. Additionally, in eight children resistance tests were performed before therapy changing. (Table 1.)

Table 1 cART efficacy

Summary of Results

6/27 (22%) children have been receiving their first regimen (the length of treatment: 10 months – 4.5 years). 21/27 (78%) patients have changed their therapies, including 12/21 (57%) with treatment failure.

Conclusions

cART in vertically HIV-infected children treated since infancy is effective. Most of the patients had to change their regimens because of treatment failure or adverse events. Multidrug resistance (double or triple class) appeared in 15% of patients.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marczyñska, M., Oldakowska, A., Dobosz, S. et al. cART in vertically HIV-infected children treated since infancy. JIAS 11, P217 (2008). https://doi.org/10.1186/1758-2652-11-S1-P217

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  • DOI: https://doi.org/10.1186/1758-2652-11-S1-P217

Keywords

  • Public Health
  • Adverse Event
  • Infectious Disease
  • Treatment Failure
  • Multidrug Resistance