cART in vertically HIV-infected children treated since infancy
© Marczyñska et al; licensee BioMed Central Ltd. 2008
Published: 10 November 2008
Purpose of the study
To evaluate cART efficacy, number of regimens and resistance development in vertically HIV-infected children treated since infancy.
ART before HAART era (before 1998)
Initial cART started without resistance testing
Initial cART based on resistance reports
10–14 yr (mean 12 yr)
10 mo – 10 yr (mean 6 yr)
2–7 yr (mean 4, 5 yr)
The first regimen
No. of cART regimens
No. of children receiving their first regimen currently
No. of children with VL<50 c/ml at evaluation
No. of patients with resistance testing before changing of ART
Single class resistance development
2 children (NRTI)
1 child (PI)
1 child (NRTI)
Double class resistance development
1 child (PI+NNRTI)
Triple class resistance development
Summary of Results
6/27 (22%) children have been receiving their first regimen (the length of treatment: 10 months – 4.5 years). 21/27 (78%) patients have changed their therapies, including 12/21 (57%) with treatment failure.
cART in vertically HIV-infected children treated since infancy is effective. Most of the patients had to change their regimens because of treatment failure or adverse events. Multidrug resistance (double or triple class) appeared in 15% of patients.
This article is published under license to BioMed Central Ltd.