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Impact of fasting bloods on hypertriglyceridemia

Purpose of the study

Abnormalities of lipid metabolism are common in HIV-infected patients and are accentuated in those receiving antiretroviral therapy, particularly with ritonavir. The measurement of non-fasting triglyceride levels is not currently common place as no standard values have been developed. The purpose of this study is to identify whether routine non-fasting bloods obtained in clinic are representative of lipid levels when compared to fasting levels.

Methods

Patients identified as having triglyceride levels above 3.0 mmol//I were requested to return for fasted sampling prior to consideration for potential intervention.

Summary of results

• 34 patients with elevated triglyceride levels were included

• All were males with a mean age of 47(± 8.6) years

See Table 1.

Table 1 Results of lipid levels when fasted.

76% of patients had a reduction in their triglyceride levels with repeated fasting. 81% of patients had a reduction in their HDL:Cholesterol ratio when bloods were repeated fasting. Both these results were statistically significant at a confidence interval of 95%.

Conclusion

All individuals should routinely have their bloods taken in the fasting state. Failure to do so may result in the inappropriate initiation of lipid-lowering agents or potential treatment changes.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Billing, N., Moyle, G. & Nelson, M. Impact of fasting bloods on hypertriglyceridemia. JIAS 11, P98 (2008). https://doi.org/10.1186/1758-2652-11-S1-P98

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  • DOI: https://doi.org/10.1186/1758-2652-11-S1-P98

Keywords

  • Lipid
  • Cholesterol
  • Lipid Metabolism
  • Lipid Level
  • Triglyceride Level