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Journal of the International AIDS Society

Open Access

Impairment of functional integrity of the vasculature is not changed in patients starting abacavir

  • S Zona1,
  • A Lattanzi1,
  • N Squillace1,
  • G Orlando1,
  • C Stentarelli1,
  • R Rossi1,
  • AC Nuzzo1,
  • MG Modena1 and
  • G Guaraldi1
Journal of the International AIDS Society200811(Suppl 1):P94

https://doi.org/10.1186/1758-2652-11-S1-P94

Published: 10 November 2008

Purpose of the study

In order to explore a possible pathogenetic mechanism of abacavir (ABC) cardiovascular toxicity, we assess the impact of beginning the drug on endothelial function via assessment of brachial artery diameter (BAD) and flow-mediated dilation (FMD).

Methods

Cross-sectional observational study that included all consecutive HIV-infected patients seen at a metabolic clinic who had BAD and FMD evaluation before and 9 months after beginning ABC as a component of a new drug regimen.

Summary of results

There were no overt metabolic, virological or antiretroviral drug-related factors associated with BAD and FMD change over time among patients starting ABC. (Figure 1)
Figure 1

FMD change over time including multipe observations.

Conclusion

Change in impairment of functional integrity of the vasculature is not an associated factor related with ABC use. Cardiovascular disease risk among HIV-infected HAART-experienced persons is likely governed by complex pathophysiologic and treatment factors.

Authors’ Affiliations

(1)
University of Modena and Reggio Emilia

Copyright

© Zona et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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