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Journal of the International AIDS Society

Open Access

Impairment of functional integrity of the vasculature is not changed in patients starting abacavir

  • S Zona1,
  • A Lattanzi1,
  • N Squillace1,
  • G Orlando1,
  • C Stentarelli1,
  • R Rossi1,
  • AC Nuzzo1,
  • MG Modena1 and
  • G Guaraldi1
Journal of the International AIDS Society200811(Suppl 1):P94

Published: 10 November 2008

Purpose of the study

In order to explore a possible pathogenetic mechanism of abacavir (ABC) cardiovascular toxicity, we assess the impact of beginning the drug on endothelial function via assessment of brachial artery diameter (BAD) and flow-mediated dilation (FMD).


Cross-sectional observational study that included all consecutive HIV-infected patients seen at a metabolic clinic who had BAD and FMD evaluation before and 9 months after beginning ABC as a component of a new drug regimen.

Summary of results

There were no overt metabolic, virological or antiretroviral drug-related factors associated with BAD and FMD change over time among patients starting ABC. (Figure 1)
Figure 1

FMD change over time including multipe observations.


Change in impairment of functional integrity of the vasculature is not an associated factor related with ABC use. Cardiovascular disease risk among HIV-infected HAART-experienced persons is likely governed by complex pathophysiologic and treatment factors.

Authors’ Affiliations

University of Modena and Reggio Emilia


© Zona et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.