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  • Poster presentation
  • Open Access

Rarity of mixed cryoglobulinemia (MC) in HIV-1 (+) treatment-naïve patients (09/2006–5/07/2008) and long-term follow-up

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Journal of the International AIDS Society200811 (Suppl 1) :P85

  • Published:


  • Public Health
  • Lymphoma
  • Clinical Outcome
  • Infectious Disease
  • Early Diagnosis

Purpose of the study

Study of the natural course of MC in HIV-1 (+) treatment-naïve patients at presentation, who will be followed-up regularly to delineate the time course of appearance and evolution or possible disappearance of MC in association with clinical and laboratory indices, therapy and clinical outcome (development of non-Hodgkin's lymphoma [NHL]).


Currently diagnosed patients (n = 67, men = 58, women = 9, mean age = 39.17 years, Greeks = 55, foreigners = 12) at their first staging examination were tested for the presence of MC. All participating patients will be followed-up every 4 months.

Summary of results

MC was found at presentation in four, in two in the first, second and third follow-up, and in the fourth and fifth follow-up, in one. Only in one patient, who was MC (+) in the first three tests, was CD8 lymphocytosis diagnosed. In the rest of the MC (+) patients, no evidence of NHL was found so far.


MC has been found to occur in 27% of HIV-1 (+) patients (1996–1997) [1], but its prevalence has declined during the HAART era (12/2003–07/2004) to 7.5% [2]. It is evident in the present study that MC is rare due possibly to earlier diagnosis and the use of HAART, but the long-term follow-up will clarify the phenomenon and give medical evidence as to whether the presence of MC is an indication for the initiation of treatment.

Authors’ Affiliations

Academic Department of Pathophysiology (AIDS Unit), Laikon GH, Medical School, Athens, Greece


  1. Dimitrakopoulos A, et al: Ann Intern Med. 1999, 130: 226-230.PubMedView ArticleGoogle Scholar
  2. Kosmas N, et al: J Med Virol. 2006, 78: 1257-61. 10.1002/jmv.20695.PubMedView ArticleGoogle Scholar


© Mourtzoukos et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.