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Different metabolic and anthropometric characteristics of TVD, CBV or KVX associated with nevirapine: Results from the "NEVIRAPINE COMPANION" cohort

Purpose of the study

To assess metabolic, anthropometric and cardiovascular risk profile of a cohort undergoing stable nevirapine therapy associated with TDF+FTC (TVD), AZT+3TC (CBV) or ABC+3TC (KVX).

Methods

Cross-sectional observational study that included all consecutive HIV-infected patients seen at a metabolic clinic undergoing nevirapine therapy for >6 months associated with TVD, CBV or KVX.

Summary of results

244 patients were included. Table 1.

Table 1

Rho of Spearman did not find any correlation between NVP exposure and the surrogate toxicity end-points (all: p = ns).

Conclusion

KVX arm displayed a greater pro-atherogenic risk profile notwithstanding lower BMI in respect to CBV and TVD. This non-randomised cohort cannot discriminate if patients with a higher underlying risk of cardiovascular disease might be initially placed on KVX or if KVX associated with NVP per se, had a poorer metabolic profile compared with the TVD and CBV arms. Careful assessment of metabolic parameters should be evaluated in people undergoing the association KVX+NEV even beyond the initial 6 months of therapy and appropriate lipid-lowering therapy started if needed.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Guaraldi, G., Adorni, F., Zona, S. et al. Different metabolic and anthropometric characteristics of TVD, CBV or KVX associated with nevirapine: Results from the "NEVIRAPINE COMPANION" cohort. JIAS 11, P34 (2008). https://doi.org/10.1186/1758-2652-11-S1-P34

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  • DOI: https://doi.org/10.1186/1758-2652-11-S1-P34

Keywords

  • Metabolic Profile
  • Risk Profile
  • Nevirapine
  • Careful Assessment
  • Anthropometric Characteristic