- Poster presentation
- Open Access
Impact on bone mineral density of tenofovir-containing HAART in HIV-1 infected children and adolescents: a report from 5 years of clinical experience
© Rosso et al; licensee BioMed Central Ltd. 2008
- Published: 10 November 2008
- Bone Mineral Density
- Bone Mass
- Bone Mineral Density Measurement
- Significant Adverse Event
Tenofovir disoproxil fumarate (TDF) is not approved for use in HIV-infected children (<18 years). In clinical practice a TAMs-sparing regimen may be needed. Use of TDF in children seems to be associated with decrease in bone mineral density that sometimes can stabilize after 24 weeks. The primary purpose was to characterized the change in bone mineral density (BMD), as measured by osteosonography (QUS), during and after treatment with tenofovir-containing HAART.
We enrolled all HIV-infected children (6–18 years), who required a change in therapy. They received TDF (children aged 2–8 years, 8 mg/kg once daily; children aged >8 years, median dose of 210 mg/m2 once daily, maximum dose of 300 mg once daily) as part of HAART, and were longitudinally observed during a follow-up of 62 months. QUS were measured at five follow-up steps: 12, 25, 35, 46, 62 months. At every step at least two patients had BMD measurements.
Our young patients do not seem to be at greater risk for bone toxicity. And a non-invasive technique, such as QUS technology, opens up new interesting perspectives, allowing following of bone mass changes in vertically infected patients and better multiple evaluation of the role of disease-related conditions or treatments able to interfere with bone mass acquisition during growth.
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This article is published under license to BioMed Central Ltd.