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"Endocrine NAFLD": a hormonocentric perspective of Non-Alcoholic Liver Disease (NAFLD) pathogenesis in HIV-infected patients

Purpose of the study

We assessed endocrine system involvement in a multifactorial pathogenesis hypothesis of NAFLD in HIV-infected patients.

Methods

Cross-sectional observational study including all consecutive HIV-infected patients seen at a metabolic clinic who were screened for diabetes, thyroid dysfunction, male hypogonadism, female menopause, hypopituitarism. NAFLD was defined by liver-spleen attenuation values of ≤1.1 on computed tomography.

Summary of results

225 patients were included. (Table 1.)

Table 1

We included endocrine variables (but not sex hormones) and known independent predicting variables (sex, waist circumference, ALT/AST, NRTI cumulative exposure) in a backward stepwise multivariate logistic regression analysis. Independent variables associated with NAFLD were NRTI cumulative exposure (OR = 1.11 per year; CI 1.01–1.20), ALT/AST (OR = 3.97; CI 1.78–8.87), waist circumference (OR = 1.06; CI 1.03–1.11). When including sex hormones in different gender groups insulin increased predictive value in female only (OR = 1.18; CI 1.03, 1.34).

Conclusion

Homeostasis of glucose appears the only endocrine system associated with NAFLD.

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Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License ( https://creativecommons.org/licenses/by-nc/2.0 ), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Stentarelli, C., Zona, S., Rochira, V. et al. "Endocrine NAFLD": a hormonocentric perspective of Non-Alcoholic Liver Disease (NAFLD) pathogenesis in HIV-infected patients. JIAS 11, P140 (2008). https://doi.org/10.1186/1758-2652-11-S1-P140

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  • DOI: https://doi.org/10.1186/1758-2652-11-S1-P140

Keywords

  • Waist Circumference
  • Hypogonadism
  • Endocrine System
  • Thyroid Dysfunction
  • Hypopituitarism