"Endocrine NAFLD": a hormonocentric perspective of Non-Alcoholic Liver Disease (NAFLD) pathogenesis in HIV-infected patients
Journal of the International AIDS Society volume 11, Article number: P140 (2008)
Purpose of the study
We assessed endocrine system involvement in a multifactorial pathogenesis hypothesis of NAFLD in HIV-infected patients.
Cross-sectional observational study including all consecutive HIV-infected patients seen at a metabolic clinic who were screened for diabetes, thyroid dysfunction, male hypogonadism, female menopause, hypopituitarism. NAFLD was defined by liver-spleen attenuation values of ≤1.1 on computed tomography.
Summary of results
225 patients were included. (Table 1.)
We included endocrine variables (but not sex hormones) and known independent predicting variables (sex, waist circumference, ALT/AST, NRTI cumulative exposure) in a backward stepwise multivariate logistic regression analysis. Independent variables associated with NAFLD were NRTI cumulative exposure (OR = 1.11 per year; CI 1.01–1.20), ALT/AST (OR = 3.97; CI 1.78–8.87), waist circumference (OR = 1.06; CI 1.03–1.11). When including sex hormones in different gender groups insulin increased predictive value in female only (OR = 1.18; CI 1.03, 1.34).
Homeostasis of glucose appears the only endocrine system associated with NAFLD.
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Cite this article
Stentarelli, C., Zona, S., Rochira, V. et al. "Endocrine NAFLD": a hormonocentric perspective of Non-Alcoholic Liver Disease (NAFLD) pathogenesis in HIV-infected patients. JIAS 11 (Suppl 1), P140 (2008). https://doi.org/10.1186/1758-2652-11-S1-P140
- Waist Circumference
- Endocrine System
- Thyroid Dysfunction