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Comparing the efficacy of Truvada® and Kivexa® combination therapy in HAART-naive individuals with different viral loads
Journal of the International AIDS Society volume 11, Article number: P14 (2008)
Purpose of the study
Truvada (emtricitabine + tenofovir) and Kivexa (abacavir + lamivudine) are combination therapies used as the nucleos(t)ide backbone in combination antiretroviral therapy. Recent reports have suggested Kivexa may be inferior to Truvada at high viral load (>100,000 copies/ml).
Retrospective case note review. All patients underwent HLA B5701 testing.
Summary of results
Between April 2006 and April 2008, 87 HAART-naive patients were commenced on either Truvada or Kivexa in combination with; efavirenz (53), nevirapine (3), Kaletra (6), atazanavir/ritonavir (9), other protease inhibitors (13). In the Truvada group (53), overall mean baseline viral load (VL) was 122,106 copies/ml. In the Kivexa group (33), overall mean baseline VL was 99,883 copies/ml. In order to assess the effect of different initial viral loads on the response to combination therapy, the patients were divided into three groups: those with High (>100,000 copies/ml), Intermediate (10,000 – 100,000 copies/ml) and Low (<10,000 copies/ml) viral loads prior to commencing HAART. (Table 1.)
Failure to achieve a viral load of less than 1,000 copies/ml by 4 weeks of therapy is strongly associated with failure to achieve long-term viral suppression. In the Truvada group, 67% of all patients achieved this level by 4 weeks of therapy. In the Kivexa group, 70% of all patients achieved a viral load of <1,000 copies/ml after 4 weeks of therapy.
There is no significant difference in clinical practice when comparing the use of Truvada and Kivexa in patients with different viral loads at commencement.
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Daniels, R., Gazzard, B., Holmes, P. et al. Comparing the efficacy of Truvada® and Kivexa® combination therapy in HAART-naive individuals with different viral loads. JIAS 11 (Suppl 1), P14 (2008). https://doi.org/10.1186/1758-2652-11-S1-P14
- Viral Load