Skip to content

Advertisement

  • Poster presentation
  • Open Access

Comparing the efficacy of Truvada® and Kivexa® combination therapy in HAART-naive individuals with different viral loads

  • 1,
  • 1,
  • 1,
  • 1,
  • 1 and
  • 1
Journal of the International AIDS Society200811 (Suppl 1) :P14

https://doi.org/10.1186/1758-2652-11-S1-P14

  • Published:

Keywords

  • Viral Load
  • Lamivudine
  • Tenofovir
  • Efavirenz
  • Nevirapine

Purpose of the study

Truvada (emtricitabine + tenofovir) and Kivexa (abacavir + lamivudine) are combination therapies used as the nucleos(t)ide backbone in combination antiretroviral therapy. Recent reports have suggested Kivexa may be inferior to Truvada at high viral load (>100,000 copies/ml).

Methods

Retrospective case note review. All patients underwent HLA B5701 testing.

Summary of results

Between April 2006 and April 2008, 87 HAART-naive patients were commenced on either Truvada or Kivexa in combination with; efavirenz (53), nevirapine (3), Kaletra (6), atazanavir/ritonavir (9), other protease inhibitors (13). In the Truvada group (53), overall mean baseline viral load (VL) was 122,106 copies/ml. In the Kivexa group (33), overall mean baseline VL was 99,883 copies/ml. In order to assess the effect of different initial viral loads on the response to combination therapy, the patients were divided into three groups: those with High (>100,000 copies/ml), Intermediate (10,000 – 100,000 copies/ml) and Low (<10,000 copies/ml) viral loads prior to commencing HAART. (Table 1.)

Table 1

 

TRUVADA

   

KIVEXA

   
 

All (mean 122,106)

VL >100,000 (mean 263,684)

VL 10–100,000 (mean 45, 772)

VL <10,000 (mean 5243)

All (mean 99,883)

VL > 100,000 (mean 256,364)

VL 10–100,000 (mean 48, 221)

VL < 10,000 (mean 6214)

Number of patients

53

20

23

10

33

9

20

4

VL <50 at 3 months (%)

60

35

74

80

73

60

80

75

Vl < 50 at 4 months (%)

75

60

87

90

79

78

85

75

VL < 50 at 6 months (%)

83

80

91

90

91

89

90

100

VL < 1000 at 4 weeks (%)

67

45

83

70

70

22

85

100

Failure to achieve a viral load of less than 1,000 copies/ml by 4 weeks of therapy is strongly associated with failure to achieve long-term viral suppression. In the Truvada group, 67% of all patients achieved this level by 4 weeks of therapy. In the Kivexa group, 70% of all patients achieved a viral load of <1,000 copies/ml after 4 weeks of therapy.

Conclusion

There is no significant difference in clinical practice when comparing the use of Truvada and Kivexa in patients with different viral loads at commencement.

Authors’ Affiliations

(1)
Chelsea & Westminster Hopsital, London, UK

Copyright

© Daniels et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Advertisement