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Statistical agreement between ultrasound (US) and computerized tomography (CT) for non-alcoholic liver disease (NAFLD) diagnosis
Journal of the International AIDS Society volume 11, Article number: P139 (2008)
Purpose of the Study
To assess K statistic of non-invasive imaging evaluations to diagnose NAFLD by means of US fatty liver indicator (FLI) score and liver to spleen attenuation ratio by CT.
Cross-sectional observational study that included all consecutive HIV-infected patients seen at a metabolic clinic who were screened for NAFLD with US and CT in the same day. HCV, HBV and heavy alcohol users (>20 g/day) were excluded. With CT, NAFLD diagnosis was defined with an L/S<1.1. US scanning was performed by a single operator. Presence and severity of steatosis was evaluated by a semiquantitative echographic score (FLI) graduated from 2 to 8. "Sine qua non" condition for the diagnosis of steatosis was the presence of liver/kidney contrast, graduated as mild/moderate (score 2) and severe (score 3). Additional criteria (score 1 each) included posterior attenuation of ultrasound beam, vessel blurring, difficult visualization of gallbladder wall or diaphragm and areas of focal sparing. US NAFLD was diagnosed by the score ≥2.
Non-invasive imaging agreement between US and CT to diagnose NAFLD is less than ideal. Best concordance is found for US ≥3 and L/S ≤1.1. Liver biopsy studies are needed to validate cut-off of US evaluation and L/S in people living with HIV.
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Cite this article
Zona, S., Ballestri, S., Lonardo, A. et al. Statistical agreement between ultrasound (US) and computerized tomography (CT) for non-alcoholic liver disease (NAFLD) diagnosis. JIAS 11, P139 (2008). https://doi.org/10.1186/1758-2652-11-S1-P139
- Computerize Tomography
- Gallbladder Wall
- Ultrasound Beam
- Alcohol User
- Imaging Agreement