- Oral presentation
- Open Access
O331 Patterns of viral suppression on cART as predictors of uncontrolled viremia after starting a new antiretroviral after 1 January 2003
© Reekie et al; licensee BioMed Central Ltd. 2008
- Published: 10 November 2008
- Public Health
- Infectious Disease
- Viral Load
- Strong Predictor
- Confounding Variable
We aimed to investigate which measures of prior viral suppression predicted uncontrolled viremia in patients on cART who started >1 antiretrovirals (ARV) after 1/1/2003.
1,807 EuroSIDA patients on cART that started any ARV after January 1, 2003 were included. Baseline was defined as the date of starting a new ARV after January 1, 2003. Poisson regression, adjusted for appropriate confounding variables, was used to identify measures of viral suppression before baseline which predicted risk of uncontrolled viremia (viral load [VL] >500 copies/ml at least 6 months after baseline) after starting a new ARV. Measures of viral suppression before baseline were number of rebounds (VL >500 copies/ml), size of rebounds, time since last rebound, highest ever rebound, and the total time suppressed and percentage of time suppressed while on cART prior to baseline.
The number of previous rebounds and the percentage of time suppressed whilst on cART were both strong predictors of future uncontrolled viremia after starting a new ARV. Hence, the history of patterns of viral response to cART regimens should be an integrated component in deciding monitoring strategies and adherence counseling for patients whenever a change in cART is made.
This article is published under license to BioMed Central Ltd.