Articles
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Citation: Journal of the International AIDS Society 2010 13(Suppl 3):O16
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Epigenetic drug Gar1041 in combination with antiretroviral therapy transiently reduces the proviral DNA reservoir in SIVmac251-infected macaques
Citation: Journal of the International AIDS Society 2010 13(Suppl 3):O14 -
Tetherin restricts direct cell-cell viral transfer and transmission of HIV-1
Citation: Journal of the International AIDS Society 2010 13(Suppl 3):O8 -
Homeostatic proliferation of memory T cells and expansion of the HIV-1 latent reservoir
Citation: Journal of the International AIDS Society 2010 13(Suppl 3):O6 -
Novel pathways of transcriptional and post-transcriptional regulation of post-integrative HIV-1 latency
Citation: Journal of the International AIDS Society 2010 13(Suppl 3):O4 -
Most HIV DNA in PBMC is present in non-gut homing, resting memory CD4+ T cells with a ß7-CD38-CD127 high phenotype
Citation: Journal of the International AIDS Society 2010 13(Suppl 3):O2 -
Workshop report: “Towards a Cure: HIV Reservoirs and Strategies to Control Them”
On 16 and 17 July 2010, immediately prior to the XVIII International AIDS Conference in Vienna, Austria, the International AIDS Society held a workshop on the important topic of moving beyond antiretroviral th...
Citation: Journal of the International AIDS Society 2010 13(Suppl 3):I1 -
Baseline severe anaemia should not preclude use of zidovudine in antiretroviral-eligible patients in resource-limited settings
Stavudine is no longer recommended as part of first-line therapy for patients initiating antiretroviral therapy (ART) in Uganda. Most patients are currently initiated on zidovudine-containing regimens, which c...
Citation: Journal of the International AIDS Society 2010 13:42 -
Targeting the hotspots: investigating spatial and demographic variations in HIV infection in small communities in South Africa
In South Africa, the severity of the HIV/AIDS epidemic varies according to geographical location; hence, localized monitoring of the epidemic would enable more effective prevention strategies. Our objectives w...
Citation: Journal of the International AIDS Society 2010 13:41 -
New diagnostics for tuberculosis: fulfilling patient needs first
An effective tuberculosis (TB) control programme requires early diagnosis and immediate initiation of treatment. Any delays in diagnosing TB not only impair a patient's prognosis, but also increase the risks o...
Citation: Journal of the International AIDS Society 2010 13:40 -
Change in condom and other barrier method use during and after an HIV prevention trial in Zimbabwe
We examined the use of male condoms and the diaphragm following completion of a clinical trial of the diaphragm's HIV prevention effectiveness. In the trial, called Methods for Improving Reproductive Health in...
Citation: Journal of the International AIDS Society 2010 13:39 -
Factors associated with access to HIV care and treatment in a prevention of mother to child transmission programme in urban Zimbabwe
This cross-sectional study assessed factors affecting access to antiretroviral therapy (ART) among HIV-positive women from the prevention of mother to child transmission HIV programme in Chitungwiza, Zimbabwe.
Citation: Journal of the International AIDS Society 2010 13:38 -
Barriers to accessing highly active antiretroviral therapy by HIV-positive women attending an antenatal clinic in a regional hospital in western Uganda
The aim of this study was to describe barriers to accessing and accepting highly active antiretroviral therapy (HAART) by HIV-positive mothers in the Ugandan Kabarole District's Programme for the Prevention of...
Citation: Journal of the International AIDS Society 2010 13:37 -
Mothers' knowledge and utilization of prevention of mother to child transmission services in northern Tanzania
More than 90% of children living with HIV have been infected through mother to child transmission. The aims of our present study were to: (1) assess the utilization of the prevention of mother to child transmi...
Citation: Journal of the International AIDS Society 2010 13:36 -
A lifeline to treatment: the role of Indian generic manufacturers in supplying antiretroviral medicines to developing countries
Indian manufacturers of generic antiretroviral (ARV) medicines facilitated the rapid scale up of HIV/AIDS treatment in developing countries though provision of low-priced, quality-assured medicines. The legal ...
Citation: Journal of the International AIDS Society 2010 13:35 -
Concurrent sexual partnerships do not explain the HIV epidemics in Africa: a systematic review of the evidence
The notion that concurrent sexual partnerships are especially common in sub-Saharan Africa and explain the region's high HIV prevalence is accepted by many as conventional wisdom. In this paper, we evaluate th...
Citation: Journal of the International AIDS Society 2010 13:34 -
Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV-1-infected South African women
Advanced HIV infection can result in lipoatrophy and wasting, even in the absence of ongoing opportunistic infections, suggesting that HIV may directly affect adipose tissue amount and distribution.
Citation: Journal of the International AIDS Society 2010 13:33 -
A process evaluation of the scale up of a youth-friendly health services initiative in northern Tanzania
While there are a number of examples of successful small-scale, youth-friendly services interventions aimed at improving reproductive health service provision for young people, these projects are often short t...
Citation: Journal of the International AIDS Society 2010 13:32 -
Discontinuation of standard first-line antiretroviral therapy in a cohort of 1434 Malawian children
The standard first-line antiretroviral (ART) regimen in Malawi for both adults and children is a fixed-dose combination tablet containing stavudine (d4T), lamivudine (3TC) and nevirapine (NVP). This regimen ha...
Citation: Journal of the International AIDS Society 2010 13:31 -
An acceptability and safety study of the Duet® cervical barrier and gel delivery system in Zimbabwe
Adherence problems with coitally dependent, female-initiated HIV prevention methods have contributed to several trials' failure to establish efficacy. Continuous use of a cervical barrier with once-daily clean...
Citation: Journal of the International AIDS Society 2010 13:30 -
High rate of loss to clinical follow up among African HIV-infected patients attending a London clinic: a retrospective analysis of a clinical cohort
Long-term regular clinic follow up is an important component of HIV care. We determined the frequency and characteristics of HIV-infected patients lost to follow up from a London HIV clinic, and factors associ...
Citation: Journal of the International AIDS Society 2010 13:29 -
Immunological response to highly active antiretroviral therapy following treatment for prevention of mother to child transmission of HIV-1: a study in Côte d'Ivoire
Information is currently limited on the long-term follow up of HIV-1 infected women who are on highly active antiretroviral therapy (HAART) that contains nevirapine and lamivudine and who were previously expos...
Citation: Journal of the International AIDS Society 2010 13:28 -
Experiences of stigma in healthcare settings among adults living with HIV in the Islamic Republic of Iran
People living with HIV (PLHIV) sometimes experience discrimination. There is little understanding of the causes, forms and consequences of this stigma in Islamic countries. This qualitative study explored perc...
Citation: Journal of the International AIDS Society 2010 13:27 -
Linking sexual and reproductive health and HIV interventions: a systematic review
The international community agrees that the Millennium Development Goals will not be achieved without ensuring universal access to both sexual and reproductive health (SRH) services and HIV/AIDS prevention, tr...
Citation: Journal of the International AIDS Society 2010 13:26 -
Low cholesterol? Don't brag yet... hypocholesterolemia blunts HAART effectiveness: a longitudinal study
In vitro studies suggest that reducing cholesterol inhibits HIV replication. However, this effect may not hold in vivo, where other factors, such as cholesterol's immunomodulatory properties, may interact.
Citation: Journal of the International AIDS Society 2010 13:25 -
Planning for pre-exposure prophylaxis to prevent HIV transmission: challenges and opportunities
There are currently several ongoing or planned trials evaluating the efficacy of pre-exposure prophylaxis (PrEP) as a preventative approach to reducing the transmission of HIV. PrEP may prove ineffective, demo...
Citation: Journal of the International AIDS Society 2010 13:24 -
AIDS-associated Kaposi's sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa
AIDS-associated Kaposi's sarcoma is an important, life-threatening opportunistic infection among people living with HIV/AIDS in resource-limited settings. In western countries, the introduction of combination ...
Citation: Journal of the International AIDS Society 2010 13:23 -
Family-centred HIV interventions: lessons from the field of parental depression
Traditionally, HIV prevention focuses on individual behaviours that place one at risk for HIV infection. Less widely regarded as a fundamental public health issue is parental depression and the detrimental eff...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):S9 -
Family-based HIV prevention and intervention services for youth living in poverty-affected contexts: the CHAMP model of collaborative, evidence-informed programme development
Family-based interventions with children who are affected by HIV and AIDS are not well established. The Collaborative HIV Prevention and Adolescent Mental Health Program (CHAMP) represents one of the few evide...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):S8 -
The impact of HIV and high-risk behaviours on the wives of married men who have sex with men and injection drug users: implications for HIV prevention
HIV/AIDS in India disproportionately affects women, not by their own risks, but by those of their partners, generally their spouses. We address two marginalized populations at elevated risk of acquiring HIV: w...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):S7 -
Children of female sex workers and drug users: a review of vulnerability, resilience and family-centred models of care
Injection drug users and female sex workers are two of the populations most at risk for becoming infected with HIV in countries with concentrated epidemics. Many of the adults who fall into these categories ar...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):S6 -
Data availability on men's involvement in families in sub-Saharan Africa to inform family-centred programmes for children affected by HIV and AIDS
The Joint Learning Initiative on Children and AIDS recently recommended that programmes for children affected by HIV and AIDS in sub-Saharan Africa direct more support to families. Interest has grown in includ...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):S5 -
Fathers and HIV: considerations for families
Fathers are intricately bound up in all aspects of family life. This review examines fathers in the presence of HIV: from desire for a child, through conception issues, to a summary of the knowledge base on fa...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):S4 -
Lessons learned from family-centred models of treatment for children living with HIV: current approaches and future directions
Despite strong global interest in family-centred HIV care models, no reviews exist that detail the current approaches to family-centred care and their impact on the health of children with HIV. A systematic re...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):S3 -
Family-centred approaches to the prevention of mother to child transmission of HIV
Prevention of mother to child transmission (PMTCT) programmes have traditionally been narrow in scope, targeting biomedical interventions during the perinatal period, rather than considering HIV as a family di...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):S2 -
An introduction to family-centred services for children affected by HIV and AIDS
Family-centred services in the context of HIV/AIDS acknowledge a broad view of a "family system" and ideally include comprehensive treatment and care, community agencies and coordinated case management. The im...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):S1 -
Visioning services for children affected by HIV and AIDS through a family lens
The HIV epidemic continues to place a great burden on children, from loss of parents and income to severe disruptions of their homes and families. Underpinned by the understanding that a healthy family constit...
Citation: Journal of the International AIDS Society 2010 13(Suppl 2):I1 -
Perceptions of rewards among volunteer caregivers of people living with AIDS working in faith-based organizations in South Africa: a qualitative study
Volunteer caregivers are a critical source of support for the majority of people living with HIV and AIDS in southern Africa, which has extremely high HIV/AIDS prevalence rates. While studies have shown that v...
Citation: Journal of the International AIDS Society 2010 13:22 -
Is there an association between PEPFAR funding and improvement in national health indicators in Africa? A retrospective study
The US President's Emergency Plan for AIDS Relief (PEPFAR) was reauthorized in June 2008 with a three-fold increase in funds, and a broader, more explicit mandate to improve health in the low- and middle-incom...
Citation: Journal of the International AIDS Society 2010 13:21 -
The experiences of people living with HIV/AIDS and of their direct informal caregivers in a resource-poor setting
HIV/AIDS is a critical concern in South Africa, where extreme poverty and gender issues are major determinants of health. A comprehensive home-based care programme is needed to lessen the burden placed on the ...
Citation: Journal of the International AIDS Society 2010 13:20 -
From project aid to sustainable HIV services: a case study from Zambia
Sustainable service delivery is a major challenge in the HIV response that is often not adequately addressed in project implementation. Sustainable strategies must be built into project design and implementati...
Citation: Journal of the International AIDS Society 2010 13:19 -
Effect of multiple micronutrient supplementation on survival of HIV-infected children in Uganda: a randomized, controlled trial
Micronutrient deficiencies compromise the survival of HIV-infected children in low-income countries. We assessed the effect of multiple micronutrient supplementation on the mortality of HIV-infected children i...
Citation: Journal of the International AIDS Society 2010 13:18 -
5th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention: summary of key research and implications for policy and practice – Operations research
Operations research was added as a fourth scientific track to the pathogenesis conference series at the 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2009) in recognition of the importance...
Citation: Journal of the International AIDS Society 2010 13(Suppl 1):S5 -
5thInternational AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention: summary of key research and implications for policy and practice – Biomedical prevention
No major findings were reported at the 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2009) on currently enrolled microbicides, pre-exposure prophylaxis (PrEP) or vaccine trials, although i...
Citation: Journal of the International AIDS Society 2010 13(Suppl 1):S4 -
5thInternational AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention: summary of key research and implications for policy and practice – Clinical sciences
Studies in several sub-Saharan African countries demonstrated that the expansion of antiretroviral therapy (ART) access is not only beneficial for people living with HIV, but also results in significant declin...
Citation: Journal of the International AIDS Society 2010 13(Suppl 1):S3 -
5thInternational AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention: summary of key research and implications for policy and practice – Basic sciences
Basic science studies at the 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2009) provided important new information that has implications not only for treatment, but also for better unders...
Citation: Journal of the International AIDS Society 2010 13(Suppl 1):S2 -
5thInternational AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention: summary of key research and implications for policy and practice - Introduction
Citation: Journal of the International AIDS Society 2010 13(Suppl 1):S1 -
Kidney function of HIV-infected children in Lagos, Nigeria: using Filler's serum cystatin C-based formula
Limited data is available on kidney function in HIV-infected children in sub-Saharan Africa. In addition, malnutrition in these children further reduces the utility of diagnostic methods such as creatinine-bas...
Citation: Journal of the International AIDS Society 2010 13:17 -
An HIV epidemic is ready to emerge in the Philippines
The state of the HIV epidemic in the Philippines has been described as "low and slow", which is in stark contrast to many other countries in the region. A review of the conditions for HIV spread in the Philipp...
Citation: Journal of the International AIDS Society 2010 13:16 -
Estimating the cost of care giving on caregivers for people living with HIV and AIDS in Botswana: a cross-sectional study
Community home-based care is the Botswana Government's preferred means of providing care for people living with HIV (PLHIV). However, primary (family members) or volunteer (community members) caregivers experi...
Citation: Journal of the International AIDS Society 2010 13:14