- Poster presentation
- Open Access
Changing antiretrovirals whilst viral load <50 copies/ml and relationship with CD4 count changes
- A Mocroft1
© Mocroft et al; licensee BioMed Central Ltd. 2010
Published: 8 November 2010
Purpose of the study
The frequency and reasons for switching antiretrovirals (ARVs) in patients on a fully suppressed cART regimen (viral load [VL] <50copies/ml) is not well described, nor is the effect of such a change on CD4 counts.
6713 patients from EuroSIDA on cART with a confirmed VL<50 copies/ml were included; a regimen change was defined as >1 ARV change (occurring on the same day) for any reason whilst VL< 50 copies/ml. Baseline was defined as the first VL<50 copies/ml on cART; Kaplan Meier methods estimated the probability of ARV change and Cox proportional hazards models, stratified by centre, identified factors associated with ARV change. Mixed models were used to model the change in CD4 count after the first ARV change.
Female versus Male
Heterosexual versus other
Per year later
Tenofovir plus 1
Abacavir plus 1
Other not listed
Positive versus negative/unknown
Changing ARVs whilst virologically suppressed was due to patient/physician choice or toxicity, increased in frequency over time and was more common in patients taking a single PI-regimen or in stavudine-containing regimens. Patients who changed ARVs had a small but statistically significant boost to CD4 count levels, and the increase in CD4 was higher in those who changed to a new class of ARV.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.