Volume 13 Supplement 4

Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection

Open Access

Role of HCV infection in the development of carotid atherosclerosis in a cohort of HIV-infected patients

  • S Ferrara1,
  • A Tartaglia2,
  • T Santantonio2 and
  • B Grisorio3
Journal of the International AIDS Society201013(Suppl 4):P204

https://doi.org/10.1186/1758-2652-13-S4-P204

Published: 8 November 2010

Background

HIV-infected patients have an increased risk of cardiovascular disease. Measurement of carotid artery intima-media-thickness (c-IMT) with colour-doppler-ultrasonography is a well-accepted, non-invasive method to assess carotid atherosclerosis.

Purpose of the study

To investigate whether HCV infection could be involved in the development of carotid atherosclerosis beside the well-known risk factors.

Patients and methods

In this cohort study, 322 consecutive HIV+ subjects were identified and enrolled between May 2009 and May 2010. A total of 153 patients were HIV/HCV co-infected, whereas 169 were HIV+ mono-infected; 237 patients were treated with highly active antiretroviral therapy (HAART), and 85 subjects were HAART-naïve. All patients underwent at least one c-IMT measurement by the same examiner; an IMT of >0.9 mm was considered pathological.

Results

Overall, 112/322 (35%) patients showed c-IMT >0.9. Table 1 shows the correlation between c-IMT and the following risk factors: age, cigarette smoking, intravenous drug use, CD4 cell count <200/mmc, CDC stage C of HIV infection, PI-based regimens and HCV co-infection. A significant statistical association between all considered factors and increased c-IMT was found. In particular, HCV co-infection showed a greater association in addition to older age, dyslipidemia, stage C of HIV infection.

Table 1

 

c-IMT<0.9

 

c-IMT> 0.9

  
 

n. 210

%

n. 112

%

p

age >40 years

121

57.6%

105

93.8%

<0.0001

cigarette smoking

42

20%

70

63%

0.03

IVDU

79

37.6%

56

50%

0.03

Cholesterolemia >200 mg/dL

50

23.8%

51

45.5%

0.0006

Triglyceridemia >170 mg/dL

58

27.6%

52

46.4%

0.0006

CDC Stage C

69

38.9%

68

60.7%

<0.0001

HAART - PI exposure

56

40.9%

81

59.1%

0.001

CD4 cell count <200/mmc

36

17.1%

36

32.1%

0.002

HCV co-infection

85

40.5%

68

60.7%

0.0005

Conclusions

In this cohort, several risk factors seem contribute to inflammatory damage and c-IMT development. Among them, HCV co-infection has been identified as a major determinant of carotid atherosclerosis. If the role of HCV infection will be confirmed in further studies, HIV-HCV co-infected patients should be strictly monitored for the vascular status.

Authors’ Affiliations

(1)
Infetious Disease Unit., Ospedali Riuniti of Foggia
(2)
Clinic of Infectious Disease, University of Foggia
(3)
Infectious Disease Unit, Ospedali Riuniti of Foggia

Copyright

© Ferrara et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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