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Role of HCV infection in the development of carotid atherosclerosis in a cohort of HIV-infected patients
Journal of the International AIDS Society volume 13, Article number: P204 (2010)
HIV-infected patients have an increased risk of cardiovascular disease. Measurement of carotid artery intima-media-thickness (c-IMT) with colour-doppler-ultrasonography is a well-accepted, non-invasive method to assess carotid atherosclerosis.
Purpose of the study
To investigate whether HCV infection could be involved in the development of carotid atherosclerosis beside the well-known risk factors.
Patients and methods
In this cohort study, 322 consecutive HIV+ subjects were identified and enrolled between May 2009 and May 2010. A total of 153 patients were HIV/HCV co-infected, whereas 169 were HIV+ mono-infected; 237 patients were treated with highly active antiretroviral therapy (HAART), and 85 subjects were HAART-naïve. All patients underwent at least one c-IMT measurement by the same examiner; an IMT of >0.9 mm was considered pathological.
Overall, 112/322 (35%) patients showed c-IMT >0.9. Table 1 shows the correlation between c-IMT and the following risk factors: age, cigarette smoking, intravenous drug use, CD4 cell count <200/mmc, CDC stage C of HIV infection, PI-based regimens and HCV co-infection. A significant statistical association between all considered factors and increased c-IMT was found. In particular, HCV co-infection showed a greater association in addition to older age, dyslipidemia, stage C of HIV infection.
In this cohort, several risk factors seem contribute to inflammatory damage and c-IMT development. Among them, HCV co-infection has been identified as a major determinant of carotid atherosclerosis. If the role of HCV infection will be confirmed in further studies, HIV-HCV co-infected patients should be strictly monitored for the vascular status.
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Ferrara, S., Tartaglia, A., Santantonio, T. et al. Role of HCV infection in the development of carotid atherosclerosis in a cohort of HIV-infected patients. JIAS 13 (Suppl 4), P204 (2010). https://doi.org/10.1186/1758-2652-13-S4-P204
- Carotid Atherosclerosis
- Vascular Status
- Great Association
- Follow Risk Factor
- Inflammatory Damage