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  • Open Access

Therapy of the patients with HIV/TB infection and dynamics of level 'naïve' CD4-lymphocytes

  • 1,
  • 2,
  • 1 and
  • 2
Journal of the International AIDS Society201013 (Suppl 4) :P196

https://doi.org/10.1186/1758-2652-13-S4-P196

  • Published:

Keywords

  • Flow Cytometry
  • Viral Load
  • Absolute Number
  • Opportunistic Infection
  • Increase Level

Background

Increase of number of patients with HIV/TB and prevalence of the given pathology in structure of the reasons of death rate of HIV-infected patients.

Objective

Study of indicators of cellular immunity and their change in the course of therapy at patients with HIV/TB.

Methods

106 patients were studied in 4 groups: 39 HIV/TB co-infected individuals (HIV+/TB+), 25 patients with HIV infection, 17 HIV-negative patients with active pulmonary TB (HIV-/TB+) and 25 healthy controls. Measures of T-cells and viral load were at baseline and after initiation of HAART and/or antitubercular therapy (4 and 12 weeks) for potential immune correlates of disease progression and prognosis. Definition immune indicators were spent by flow cytometry (BD Biosciences, USA).

Results

Before treatment: percent of CD4+CD45RA+ differs in investigated groups. The lowest values registered at patients of 1 and 2 groups (fig.1). For patients in the group 3, the deviation of the given indicator from control group was small. If HAART and antitubercular therapy were effective we registered increase level % CD4+CD45RA+ in all groups. ∆ % CD4+CD45RA+ increased more slowly in patients of group 1. The same results turn out at research of absolute number CD4+CD45RA+ in all groups.

Figure 1

Conclusions

Low-level % CD4+CD45RA+ in patients with HIV/TB and HIV infection is connected with the general decrease ÑD4-lymphocytes. After first months of efficient therapy of patients with HIV/TB, infringements in immune system still remained, which, probably, are caused by joining of opportunistic infections.

Authors’ Affiliations

(1)
Peoples’ Friendship University of Russia, Moscow, Russian Federation
(2)
Russian Federal AIDS Center, Moscow, Russian Federation

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