- Poster presentation
- Open Access
Therapy of the patients with HIV/TB infection and dynamics of level 'naïve' CD4-lymphocytes
© Popova et al; licensee BioMed Central Ltd. 2010
Published: 8 November 2010
Increase of number of patients with HIV/TB and prevalence of the given pathology in structure of the reasons of death rate of HIV-infected patients.
Study of indicators of cellular immunity and their change in the course of therapy at patients with HIV/TB.
106 patients were studied in 4 groups: 39 HIV/TB co-infected individuals (HIV+/TB+), 25 patients with HIV infection, 17 HIV-negative patients with active pulmonary TB (HIV-/TB+) and 25 healthy controls. Measures of T-cells and viral load were at baseline and after initiation of HAART and/or antitubercular therapy (4 and 12 weeks) for potential immune correlates of disease progression and prognosis. Definition immune indicators were spent by flow cytometry (BD Biosciences, USA).
Low-level % CD4+CD45RA+ in patients with HIV/TB and HIV infection is connected with the general decrease ÑD4-lymphocytes. After first months of efficient therapy of patients with HIV/TB, infringements in immune system still remained, which, probably, are caused by joining of opportunistic infections.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.