Skip to main content
  • Poster presentation
  • Open access
  • Published:

Therapy of the patients with HIV/TB infection and dynamics of level 'naïve' CD4-lymphocytes


Increase of number of patients with HIV/TB and prevalence of the given pathology in structure of the reasons of death rate of HIV-infected patients.


Study of indicators of cellular immunity and their change in the course of therapy at patients with HIV/TB.


106 patients were studied in 4 groups: 39 HIV/TB co-infected individuals (HIV+/TB+), 25 patients with HIV infection, 17 HIV-negative patients with active pulmonary TB (HIV-/TB+) and 25 healthy controls. Measures of T-cells and viral load were at baseline and after initiation of HAART and/or antitubercular therapy (4 and 12 weeks) for potential immune correlates of disease progression and prognosis. Definition immune indicators were spent by flow cytometry (BD Biosciences, USA).


Before treatment: percent of CD4+CD45RA+ differs in investigated groups. The lowest values registered at patients of 1 and 2 groups (fig.1). For patients in the group 3, the deviation of the given indicator from control group was small. If HAART and antitubercular therapy were effective we registered increase level % CD4+CD45RA+ in all groups. ∆ % CD4+CD45RA+ increased more slowly in patients of group 1. The same results turn out at research of absolute number CD4+CD45RA+ in all groups.

figure 1

Figure 1


Low-level % CD4+CD45RA+ in patients with HIV/TB and HIV infection is connected with the general decrease ÑD4-lymphocytes. After first months of efficient therapy of patients with HIV/TB, infringements in immune system still remained, which, probably, are caused by joining of opportunistic infections.

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Popova, A., Kravchenko, A., Kozhevnikova, G. et al. Therapy of the patients with HIV/TB infection and dynamics of level 'naïve' CD4-lymphocytes. JIAS 13 (Suppl 4), P196 (2010).

Download citation

  • Published:

  • DOI: