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Therapy of the patients with HIV/TB infection and dynamics of level 'naïve' CD4-lymphocytes
Journal of the International AIDS Society volume 13, Article number: P196 (2010)
Increase of number of patients with HIV/TB and prevalence of the given pathology in structure of the reasons of death rate of HIV-infected patients.
Study of indicators of cellular immunity and their change in the course of therapy at patients with HIV/TB.
106 patients were studied in 4 groups: 39 HIV/TB co-infected individuals (HIV+/TB+), 25 patients with HIV infection, 17 HIV-negative patients with active pulmonary TB (HIV-/TB+) and 25 healthy controls. Measures of T-cells and viral load were at baseline and after initiation of HAART and/or antitubercular therapy (4 and 12 weeks) for potential immune correlates of disease progression and prognosis. Definition immune indicators were spent by flow cytometry (BD Biosciences, USA).
Before treatment: percent of CD4+CD45RA+ differs in investigated groups. The lowest values registered at patients of 1 and 2 groups (fig.1). For patients in the group 3, the deviation of the given indicator from control group was small. If HAART and antitubercular therapy were effective we registered increase level % CD4+CD45RA+ in all groups. ∆ % CD4+CD45RA+ increased more slowly in patients of group 1. The same results turn out at research of absolute number CD4+CD45RA+ in all groups.
Low-level % CD4+CD45RA+ in patients with HIV/TB and HIV infection is connected with the general decrease ÑD4-lymphocytes. After first months of efficient therapy of patients with HIV/TB, infringements in immune system still remained, which, probably, are caused by joining of opportunistic infections.
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Popova, A., Kravchenko, A., Kozhevnikova, G. et al. Therapy of the patients with HIV/TB infection and dynamics of level 'naïve' CD4-lymphocytes. JIAS 13, P196 (2010). https://doi.org/10.1186/1758-2652-13-S4-P196
- Flow Cytometry
- Viral Load
- Absolute Number
- Opportunistic Infection
- Increase Level