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Health-related quality of life and fatigue in HIV-1 infected patients diagnosed during primary versus chronic infection
© Steingrover et al; licensee BioMed Central Ltd. 2010
Published: 8 November 2010
Health-related quality of life (HRQOL) is affected by chronic HIV-infection (CHI). No data are available if and to what extent HRQOL is affected in patients who were diagnosed during primary HIV-1 infection (PHI).
Included were Dutch, male, adult, HIV-1 infected patients, attending the AMC outpatient clinic who seroconverted after December 31st of 1996. 59 Patients identified during PHI and a randomly selected group of 99 patients that were identified with CHI in the same period were eligible. Patients were excluded if they ever had an CDC-C event or suffered any significant comorbidity. Subjects were asked to complete the SF-36 and the Multidimensional Fatigue Inventory (MFI-20) questionnaires. SF-36 and MFI-20 scores were compared with age- and gender-matched Dutch or German general population norms, respectively.
HIV-infected patients in the HAART-era have severely impaired HRQOL and suffer from fatigue. Patients that presented with PHI in the past are impaired to a larger extent and in more dimensions than patients diagnosed with HIV during CHI. This difference is present in both HRQOL and fatigue.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.