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- Open Access
Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study
© Kirk et al; licensee BioMed Central Ltd. 2010
Published: 8 November 2010
Purpose of study
Since 25-hydroxy vitamin D (25(OH)D) deficiency has been associated with higher risk of morbidity and mortality in different settings, this study examined the association between 25(OH)D level and disease progression in HIV-infected patients with prospective follow-up in the EuroSIDA study.
A group of 2000 patients were randomly selected from those with stored samples after stratification by region. 25(OH)D levels were measured in a single laboratory from stored plasma samples. The 1985 available 25(OH)D results were stratified into tertiles. Factors associated with 25(OH)D levels and associations of 25(OH) levels with subsequent risk of all-cause mortality, AIDS and non-AIDS events were analysed, using Poisson regression.
This observational study demonstrated that 25(OH)D deficiency is frequent in HIV-infected patients, and is independently associated with a variety of outcomes, reflected by a higher risk of mortality and AIDS events. Whether the relationship between vitamin D deficiency and clinical events is causal should be addressed because of potentially major consequences in terms of public health.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.