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Cardiovascular risk assessment in persons with HIV in the developing world: comparing three risk equations in a cohort of HIV-infected Thais
© Edwards-Jackson et al; licensee BioMed Central Ltd. 2010
Published: 8 November 2010
There are growing concerns of cardiovascular disease in HIV-infected individuals and in developing countries, such as Thailand. We described the ten-year risk of coronary heart disease (CHD) in a Thai HIV-infected cohort using 3 cardiovascular risk equations, and assessed the level of agreement between their predictions.
Cross-sectional analysis of data from 785 Thai subjects followed prospectively in the HIV Netherlands Australia Thailand Collaboration (HIV-NAT) cohort study from 1996-2009. Cardiovascular risk factor history, along with relevant laboratory and clinical data, was collected at follow-up clinic visits. Ten-year risks of CHD were calculated using the Framingham, Ramathibodi-Electricity Generating Authority of Thailand (Rama-EGAT), and Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) risk equations.
The predicted cardiovascular risk in this HIV-infected Thai cohort was relatively low. The Framingham equation predicted the highest cardiovascular risks, which is consistent with its known tendency to over-predict risk in Thais. The agreement between the Rama-EGAT and D:A:D risk scores suggests that both equations may be appropriate estimators of cardiovascular risk in this and other developing world populations with low background risk.
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