- Oral presentation
- Open Access
Cardiovascular risk assessment in persons with HIV in the developing world: comparing three risk equations in a cohort of HIV-infected Thais
© Edwards-Jackson et al; licensee BioMed Central Ltd. 2010
- Published: 8 November 2010
- Coronary Heart Disease
- Risk Score
- Framingham Risk Score
- High Cardiovascular Risk
- Risk Equation
There are growing concerns of cardiovascular disease in HIV-infected individuals and in developing countries, such as Thailand. We described the ten-year risk of coronary heart disease (CHD) in a Thai HIV-infected cohort using 3 cardiovascular risk equations, and assessed the level of agreement between their predictions.
Cross-sectional analysis of data from 785 Thai subjects followed prospectively in the HIV Netherlands Australia Thailand Collaboration (HIV-NAT) cohort study from 1996-2009. Cardiovascular risk factor history, along with relevant laboratory and clinical data, was collected at follow-up clinic visits. Ten-year risks of CHD were calculated using the Framingham, Ramathibodi-Electricity Generating Authority of Thailand (Rama-EGAT), and Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) risk equations.
The predicted cardiovascular risk in this HIV-infected Thai cohort was relatively low. The Framingham equation predicted the highest cardiovascular risks, which is consistent with its known tendency to over-predict risk in Thais. The agreement between the Rama-EGAT and D:A:D risk scores suggests that both equations may be appropriate estimators of cardiovascular risk in this and other developing world populations with low background risk.
- Expert Panel of Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001, 285 (19): 2486-2497. 10.1001/jama.285.19.2486.View ArticleGoogle Scholar
- Yamwong S: Final report. The development of coronary heart disease assessment [technical report on the Internet]. Bangkok (Thailand): National Health Foundation (ThaiNHF). 2005, Dec [cited 2009 Oct 9]. 17 p. Contract No.: PDG4830206. Available from: http://hrn.thainhf.org/index.php?module=research&view=detail&act=ok&rid=67 using login name and password. ThaiGoogle Scholar
- Fris-Møller N, Thiébaut R, Reiss P, Weber R, D'Arminio Monforte A, De Wit S, et al: Predicting the risk of cardiovascular disease in HIV-infected patients; the Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) Study. Eur J Cardiovasc Prev Rehabil.Google Scholar
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