- Oral presentation
- Open Access
Fatal and non-fatal AIDS and non-AIDS events in HIV-1 infected patients with high CD4 counts
© Reekie et al; licensee BioMed Central Ltd. 2010
Published: 8 November 2010
The risk of uncontrolled viral replication in HIV+ patients who are not immune compromised on the development of serious clinical events is not fully understood. We aimed to compare the incidence of fatal and non-fatal AIDS and non-AIDS events occurring at CD4 counts >350 cells/mm3 in different viral load strata (≤500, 501-10000, >10000 copies/ml).
Patients contributed person years at risk if the most recent CD4 count was >350 cells/mm3 and viral load was measured in the 6 months prior. Poisson regression investigated the relationship between viremia and clinical events, after adjustment for confounding variables.
In patients with a CD4 count >350 cells/mm3 an increased incidence of fatal and non-fatal AIDS and non-AIDS events was found in patients with uncontrolled viral replication, even after adjustment for current CD4 count and use of cART. The association between viral replication and AIDS events was clear and consistent with a biological effect, but with non-AIDS events was less clear without a difference between intermediate and high viral replication.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.