Immune restoration during HAART: 8-year follow-up in HIV-positive patients with sustained virological suppression
Journal of the International AIDS Society volume 11, Article number: P10 (2008)
Purpose of the study
Durable virological suppression during HAART is associated with immunological recovery in patients with HIV infection. Current guidelines recommend to initiate HAART when CD4+ cell count falls <350/μl. However, recent studies have shown a higher immune restoration when HAART was started at CD4+ baseline level > 350 cells/μl. We retrospectively assessed the long-term immunological outcome in patients with sustained virological suppression during HAART, for up to 8 years.
HIV-infected consecutive patients attending to our clinic were included, with the following inclusion criteria: follow-up >1 year while on HAART and sustained virologic suppression (HIV-RNA <400 copies/ml) for at least 6 consecutive months. We analyzed the immunological outcome by of annual determination of: 1) CD4+ cell count; and 2) change in CD4+ cell count from baseline. Complete immunological recovery was defined as CD4+ cell count ≥700/μl. Patients were stratified according to baseline CD4+ cell (counts of <200/μl, 200–350/μl and >350/μl), age, HIV risk group, HCV co-infection, HAART regimen, sex, and race. A statistical analysis was performed by linear regression.
Summary of results
352 patients were observed: 172, 85 and 95 patients had baseline CD4+ cell count <200/μl, 200–350/μl and >350/μl, respectively. After 5 years of therapy, 29%, 69% and 82% of patients with baseline CD4+ cell count, respectively, <200/μl, 200–350/μl and >350/μl, exceeded the threshold of 500 cells/μl (p = 0.034).
Among patients with baseline CD4+ cell count >350/μl, mean CD4+ cell count reached a plateau with a complete immunological recovery by 4 years of suppressive HAART. CD4+ cell count increased even after 8 years without ever reaching a full immunological recovery in patients with baseline CD4+ cell count <200/μl.
Patients aged ≥50 years had a slower but similar immune recovery (p > 0.05). We found no significant differences in immunological response according to baseline viral load, HIV risk factor, sex, HCV co-infection and HAART regimen.
In our study, patients with sustained viral suppression experienced a significant immune recovery over 8 years of HAART. We found that complete immune recovery was achieved only in patients with baseline CD4+ cell count >350/μl. This observation strengthens the hypothesis that starting HAART at CD4+ cell counts < 50/μl could not be adequate to obtain a complete immunological recovery.
Moore D, Keruly JC: CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression. CID. 2007, 44: 441-6. 10.1086/510746.
Gras L, et al: CD4 cell counts of 800 cells/mmc or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cell/mmc or greater. J AIDS. 2007, 45 (2): 183-192.
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Cite this article
Malincarne, L., Sgrelli, A., Camanni, G. et al. Immune restoration during HAART: 8-year follow-up in HIV-positive patients with sustained virological suppression. JIAS 11 (Suppl 1), P10 (2008). https://doi.org/10.1186/1758-2652-11-S1-P10
- Cell Count
- Viral Suppression
- Virological Suppression
- Immune Recovery
- Baseline Viral Load