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Table 2 Comparison between HIV-1 seronegative psoriasis and HIV-1 related psoriasis

From: New insights into HIV-1-primary skin disorders

Variable HIV-1-seronegative psoriasis HIV-1-related psoriasis References
Frequency 1-3% Similar to HIV-seronegative population [54, 55]
Severity Mild-moderate Moderate-severe [62]
Clinical features Erythematous plaques usually circumscribed to elbows-knees (psoriasis vulgaris) More extensive lesions
Increased presence of acral lesions and inverse psoriasis
[4, 55]
Histhopatological features Hyperproliferation and hyperkeratosis, lymphocytic infiltrate and absence of granular layer Same [55]
Presence of psoriatic arthritis 5-20% 23%-50% [54, 55]
Mean age of presentation >30 years =30 years [63]
Family history Frequent Variable [64]
Presence of HLA-Cw*0602 25% 79% [64]
Presence of Reiter's Syndrome Rare Frequent [54]
Development of erythroderma +/+++ ++/+++ [65]
Response to conventional treatment (topical steroids, Vitamin D analogues, phototherapy) Variable Variable-poor [63, 66]
Response to zidovudine/HAART +/+++ ++/+++ [67, 68]