New insights into HIV-1-primary skin disorders

Table 2 Comparison between HIV-1 seronegative psoriasis and HIV-1 related psoriasis

Variable	HIV-1-seronegative psoriasis	HIV-1-related psoriasis	References
Frequency	1-3%	Similar to HIV-seronegative population	[54, 55]
Severity	Mild-moderate	Moderate-severe	[62]
Clinical features	Erythematous plaques usually circumscribed to elbows-knees (psoriasis vulgaris)	More extensive lesions Increased presence of acral lesions and inverse psoriasis	[4, 55]
Histhopatological features	Hyperproliferation and hyperkeratosis, lymphocytic infiltrate and absence of granular layer	Same	[55]
Presence of psoriatic arthritis	5-20%	23%-50%	[54, 55]
Mean age of presentation	>30 years	=30 years	[63]
Family history	Frequent	Variable	[64]
Presence of HLA-Cw*0602	25%	79%	[64]
Presence of Reiter's Syndrome	Rare	Frequent	[54]
Development of erythroderma	+/+++	++/+++	[65]
Response to conventional treatment (topical steroids, Vitamin D analogues, phototherapy)	Variable	Variable-poor	[63, 66]
Response to zidovudine/HAART	+/+++	++/+++	[67, 68]