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  • Poster presentation
  • Open Access

Cost-efficacy analysis of the MONET trial using Spanish antiretroviral drug prices

  • 1,
  • 2,
  • 3 and
  • 4
Journal of the International AIDS Society201013 (Suppl 4) :P235

https://doi.org/10.1186/1758-2652-13-S4-P235

  • Published:

Keywords

  • Triple Therapy
  • Phenotypic Resistance
  • Lower Treatment
  • Drug Price
  • Lower Treatment Cost

Background

In virologically suppressed patients, switching to DRV/r monotherapy maintains HIV RNA suppression, and could also lower treatment costs.

Methods

In the MONET trial 256 patients with HIV RNA <50 copies/mL on current HAART for over 24 weeks (NNRTI based (43%), or PI based (57%)), switched to DRV/r 800/100 mg once daily, either as monotherapy (n=127) or with 2NRTI (n=129). The Spanish costs per patient with HIV RNA below 50 copies/mL were calculated, using a "switch included" analysis at Week 96, to account for additional antiretrovirals taken after initial treatment failure. Published prices were used.

Results

In the ITT switch included analysis, HIV RNA <50 copies/mL by Week 96 was 92.1% versus 90.7% in the DRV/r monotherapy and control arms. No patients in either arm developed phenotypic resistance to DRV. Before the trial, the mean annual cost of antiretrovirals was €4612 for patients on NNRTI based HAART, and €9217 for patients on PI based HAART. During the MONET trial, the mean annual per-patient cost of antiretrovirals was €9915 in the triple therapy arm, of which 45% was from NRTIs and 55% from PIs. The mean per-patient cost in the monotherapy arm was €5915, a saving of 40%. We estimated 65,000 people treated with antiretrovirals in Spain (50% NNRTI based, 50% PI based) and 15% of patients (9,750) eligible for PI monotherapy. A switch to DRV/r monotherapy could cut the two-year cost of antiretroviral treatment for these patients, from €137 million to €115 million, a saving of €22 million over two years.

Conclusions

Based on the MONET results, the lower cost of DRV/r monotherapy versus triple therapy in Spain would allow more patients to be treated for a fixed budget, or a saving of up to €22 million over two years, if all eligible patients were switched, while maintaining HIV RNA suppression below 50 copies/mL.

Authors’ Affiliations

(1)
Hospital La Paz, Madrid, Spain
(2)
Liverpool University, Liverpool, UK
(3)
Janssen-Cilag, Madrid, Spain
(4)
Janssen France, Issy-les-Moulineaux, France

Copyright

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