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Trends in human papillomavirus (HPV) infection among HIV-positive women in the pre-HAART and HAART era in a Nigerian clinic

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Journal of the International AIDS Society201013 (Suppl 4) :P217

  • Published:


  • Care Provider
  • Incidence Rate
  • Latency Period
  • Retrospective Review
  • Rate Ratio


The prevalence of HIV infection has been on the increase in Nigeria in recent times. HIV-positive patients frequently have anogenital malignancies due to HPV. HAART was introduced in Anti-retroviral (ARV) centers in Nigeria in the year 2002.

Purpose of the study

To determine trends in incidence of anogenital malignancies among HIV-positive women undergoing treatment in the clinic in the pre-HAART and HAART era.


A retrospective review of 541 case notes of HIV-positive female patients from January 1999 to December 2004 were analyzed by utilizing an on-going observational database at the ARV center. Rate ratios, comparing incidence rates (number of malignancies per 1000 person years) were calculated.


Twenty-four (4.43%) of the patients had one form of anogenital manifestation of HPV or the other. The incidence rate for HPV rose from 2.28 in the pre-HAART era to 6.40 in the HAART era (Rate ratio = 3.15; 95% confidence interval (CI) =1.31 - 7.44; p= 0.0002).


There has been a significant rise in the incidence of HPV since the introduction of HAART. This may be due to the longer survival of HIV-infected patients, surpassing the latency period for the anogenital malignancies. Care providers should be more vigilant for HIV-associated malignancies as patients live longer in this part of the world.

Authors’ Affiliations

Lagos University Teaching Hospital, Community Medicine, Lagos, Nigeria


© Onigbogi and Ojo; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.