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- Open Access
Do interleukin-28B single nucleotide polymorphisms influence the natural history of chronic hepatitis B?
© Martín-Carbonero et al; licensee BioMed Central Ltd. 2010
- Published: 8 November 2010
- Single Nucleotide Polymorphism
- Natural History
- Chronic Hepatitis
- Case Control Study
Single nucleotide polymorphisms (SNPs) nearby the IL28B gene have been associated with spontaneous hepatitis C virus (HCV) clearance and response to interferon-based therapies in both HCV-monoinfected and HIV-HCV co-infected patients. However, little is known about the impact of IL28B SNPs on HBV natural history.
A case control study was performed in which cases were HIV+ patients with chronic hepatitis B (HBsAg+ for >6 months). All were genotyped for the rs12979860 SNP (protective CC genotype). One control for each case was chosen among HIV patients with anti-HBs and anti-HBc. Controls were matched for gender and coinfection with HCV.
A total of 49 cases fit the inclusion criteria. Most were male (90%), with a median (IQR) age of 42.6 (39-46.7) years-old. Eighteen (36.7%) were or had been chronic infected by HCV. Among HBsAg+ patients, 19 (41.3%) were HBeAg+ and 13 (26.5%) were superinfected by the hepatitis delta virus (HDV). No differences were found in the distribution of CC genotypes when comparing patients with chronic hepatitis B and those who spontaneously cleared HBsAg (59.2% vs 44.9%, respectively; p=0.3).
There is no evidence for a beneficial role of the IL-28B CC genotype on the development of chronic hepatitis B in HIV-coinfected patients.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.