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Do interleukin-28B single nucleotide polymorphisms influence the natural history of chronic hepatitis B?

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Journal of the International AIDS Society201013 (Suppl 4) :P205

  • Published:


  • Hepatitis
  • Single Nucleotide Polymorphism
  • Natural History
  • Chronic Hepatitis
  • Case Control Study


Single nucleotide polymorphisms (SNPs) nearby the IL28B gene have been associated with spontaneous hepatitis C virus (HCV) clearance and response to interferon-based therapies in both HCV-monoinfected and HIV-HCV co-infected patients. However, little is known about the impact of IL28B SNPs on HBV natural history.


A case control study was performed in which cases were HIV+ patients with chronic hepatitis B (HBsAg+ for >6 months). All were genotyped for the rs12979860 SNP (protective CC genotype). One control for each case was chosen among HIV patients with anti-HBs and anti-HBc. Controls were matched for gender and coinfection with HCV.


A total of 49 cases fit the inclusion criteria. Most were male (90%), with a median (IQR) age of 42.6 (39-46.7) years-old. Eighteen (36.7%) were or had been chronic infected by HCV. Among HBsAg+ patients, 19 (41.3%) were HBeAg+ and 13 (26.5%) were superinfected by the hepatitis delta virus (HDV). No differences were found in the distribution of CC genotypes when comparing patients with chronic hepatitis B and those who spontaneously cleared HBsAg (59.2% vs 44.9%, respectively; p=0.3).


There is no evidence for a beneficial role of the IL-28B CC genotype on the development of chronic hepatitis B in HIV-coinfected patients.

Authors’ Affiliations

Hospital Carlos III, Madrid, Spain


© Martín-Carbonero et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.