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  • Open Access

High prevalence of genotype G in HIV co-infected patients compared with HBV monoinfected patients in México

  • 1,
  • 1,
  • 2 and
  • 3
Journal of the International AIDS Society201013(Suppl 4):P201

https://doi.org/10.1186/1758-2652-13-S4-P201

Published: 8 November 2010

Keywords

  • Viral Load
  • Resistance Pattern
  • Genotype Prevalence
  • Binomial Confidence Interval
  • Monoinfected Patient

Background

It has been reported in Mexico that genotypes H and G are the most common, although genotypes prevalence in HIV co-infected patients is unknown.

Purpose of the study

We estimated the prevalence and identified the resistance pattern of HBV/H and G genotypes in HIV co-infected patients and compared them in mono-infected HBV patients.

Methods

A cross-sectional prevalence and analytic study were realized. Risk factors, HIV or HCV co-infections, antiretroviral therapy (ART) experience, HBsAg, HBeAg, HBV viral load and mutations genetic analysis were collected; CD4+ cells count from HIV co-infected patients and HIV viral load were measured. We calculated the prevalence and exact 95% binomial confidence interval as well the Odds ratios (OR) and 95% confidence intervals to assess the relationship between risks factors and the risk of having HBV/H or G genotype.

Results

We enrolled 84 patients, 72 men and 12 women with 41 HIV co-infected patients. The distribution of HBV genotypes was: HBV/H 56 (66%), HBV/G 22 (26.1% [95% CI 17% to 36%]), HBV/F 4 (4.7%) and HBV/A 2 (2.3%). The most frequent mutations presented in 9 HIV co-infected patients and one mono-infected patient with ART experience were rtM204V and seven of them showed genotype G (7/9). Mono-infected HBV patients exposed more probability to HBV/H genotype than co-infected HIV patients OR 13.0 (CI 95% 3.40-49.79), P=0.0001 In contrast co-infected patients presented less possibility to have genotype H, 0.56 (CI 95% 0.42-0.75).

Conclusions

Our results suggest that HBV/G genotype predominates in co-infected patients. As well, rtM204V and rtL180M mutations are common in HBV/HIV co-infected patients with genotype G and ART experience.

Authors’ Affiliations

(1)
Hospital de Infectología "La Raza" National Medical Center/IMSS, Infectious diseases, Mexico City, Mexico
(2)
Hospital de Cardiología/IMSS, Clinical Pathology, Mexico City, Mexico
(3)
UIMII "La Raza" National Medical Center/IMSS, Mexico City, Mexico

Copyright

© Arroyo-Anduiza et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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