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Table 4 Crude and adjusted hazard ratios of death and loss to follow up stratified by missed visit status among ART patients in Johannesburg, South Africa (n = 4476)

From: The importance of clinic attendance in the first six months on antiretroviral treatment: a retrospective analysis at a large public sector HIV clinic in South Africa

Visit type

No. Events

(%)

Person

time

(years)

Rate (per

100 person

years)

Crude HR

(95% CI)

Adjusted HR‡

(95% CI)

Death §

Medical visits

     

   0

76 (2.3%)

3080.6

2.5

Reference

Reference

   1

28 (2.7%)

984.4

2.8

1.15 (0.75-1.78)

1.11 (0.72-1.72)

   2

8 (4.9%)

152.2

5.3

2.12 (1.03-4.40)

2.06 (1.00-4.28)

   ≥ 3

3 (15.0%)

15.7

19.1

7.69 (2.43-24.4)

4.74 (1.39-16.2)

ARV visits

     

   0

90 (2.6%)

3309.3

2.7

Reference

Reference

   1

23 (2.7%)

806.5

2.9

1.05 (0.66-1.66)

1.02 (0.65-1.62)

   2

0 (0%)

107.8

0

-

-

   ≥ 3

2 (18.2%)

9.3

21.5

7.87 (1.94-32.0)

8.15 (1.97-33.7)

Lost to follow up ^

Medical visits

     

   0

196 (6.0%)

3080.6

6.4

Reference

Reference

   1

62 (5.9%)

984.4

6.3

0.99 (0.75-1.32)

0.97 (0.73-1.30)

   2

15 (9.1%)

152.2

9.9

1.55 (0.92-2.63)

1.54 (0.91-2.61)

   ≥ 3

4 (22.0%)

15.7

25.5

4.07 (1.51-10.9)

2.98 (1.10-8.14)

ARV visits

     

   0

196 (5.6%)

3309.3

5.9

Reference

Reference

   1

57 (6.6%)

806.5

7.1

1.20 (0.89-1.61)

1.20 (0.89-1.61)

   2

24 (19.8%)

107.8

22.3

3.80 (2.48-5.80)

3.81 (2.48-5.84)

   ≥ 3

0 (0%)

9.3

0

-

-

  1. ‡ Hazard ratios (HR) are from a Cox proportional regression models adjusted for age, sex, total number of scheduled visits, baseline regimen and CD4 count after nine months on ART
  2. § Death obtained from South African National Vital Registration Infrastructure Initiative
  3. ^Lost to follow up defined as ≥4 months since last visit
  4. CI, confidence interval