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Table 4 Frequency of mutations within RT.

From: Five-year follow up of genotypic resistance patterns in HIV-1 subtype C infected patients in Botswana after failure of thymidine analogue-based regimens

Mutations

Frequency (%)

*P value

 

Group 1

Group 2

 

NNRTI

   

A98S/G

26.9

18.9

-

K101E/Q/P/R

19.23

21.6

-

K103N

34.6

48.6

-

V106M

30.8

16.21

-

V108I

15.4

18.9

-

E138A

15.4

27

-

V179E/D

15.3

13.5

-

Y181C

23

27

-

Y188L

0

13.5

-

G190A

23

13.5

-

NRTI (non-TAM)

   

K65R

7.7

0

-

S68G

19.2

8.1

-

L74V/I

7.7

16.2

-

Q151M

3.8

2.7

-

M184V

61

40.5

-

TAM1

   

41L

26.9

40.5

-

210W

19.2

18.9

-

215Y

26.9

29.7

-

TAM2

   

67N

46

67.56

0.07

70R

35

37.8

-

215F

26.9

29.7

-

219Q

34.6

37.8

-

Others

   

E53D

11.5

13.5

-

K102R/Q/N

15.4

0

-

I135V/T

30.8

45.9

-

T139A/P/S

0

16.2

-

I142V/T

15.4

8.1

-

A158S

23

0

-

S162C/A/T

15.4

24.3

-

I178L/M

19

35

-

I202V

34.6

8

0.008

E203A/K/D

3.8

18.9

-

H221Y

11.5

18.9

-

L228R/H

8

27

0.05

D250E

42.3

40.5

-

K275R/Q

23

8

0.09

D324E

27

8

0.04

  1. * P value: probability of significant differences between groups