Table 1
From: Antivirals and nuclear receptor activation of CYP3A4 and 2B6
| Â | Â | Fold Induction | Â | Â |
|---|---|---|---|---|
Approx. Clinical Conc | PXR/CYP3A4 | CAR/CYP3A4 | PXR/CYP2B6 | CAR/CYP2B6 |
IDV (15 μM) | 1.3 | <1 | 1.5 | <1 |
NFV (6 μM) | 6.1 | <1 | 3.0 | <1 |
LPV (16 μM) | 9.1 | <1 | 8.6 | 1.6 |
RTV (1 μM) | 1.9 | <1 | 2.1 | <1 |
TFV (1 μM) | <1 | 1.2 | ND | ND |
SQV (4 μM) | 3.2 | <1 | ND | ND |
NVP (7.5 μM) | <1 | 1.1 | <1 | 1.6 |
EFV (10 μM) | 5.8 | <1 | 2.6 | <1 |
FOS (13 μM) | 10.4 | 1.4 | 2.9 | 1.3 |
Rifampicin (10 μM) | 18.3 | --- | 15.9 | --- |
CITCO (100 nM) | --- | 3.4 | --- | 3.5 |