HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy

Table 1 Measurements are mean (+/- SD). RNA expressions are in arbitrary units. * control vs. HIV naïve, control vs. HIV 6 mth * HIV naïve vs. HIV 6 mth.

	Control	HIV Naive	HIV AZT 6 m	HIV TDF 6 m	p all HIV 6 m
Adiponectin ug/ml	8.2 (4.9)	10.3 (4.1)	13.3 (6.8) p = 0.025, *p = 0.05	9.4 (3.3)	0.04, *0.01
Hepatic lipase nmol/ml/h	200 (119)	126 (80)	148 (110)	137 (93)	NS
LPL nmol/ml/h	528 (151)	297 (107) *p = 0.0001	382 (212) p = 0.05, *p = 0.05	341 (167) **p = 0.12	**0.008
LPL mRNA	173 (106)	188 (97)	187 (68) **p = 0.05	167 (114) **NS	0.004, *0.007
HSL mRNA	0.38 (0.29)	0.38 (0.29)	1.2 (1.5) p = 0.05, *p = 0.05	1.3 (1.6) p = 0.02, *p = 0.015	0.02, *0.001
Adiponectin mRNA	30.9 (25.4)	26.1 (9.1)	39.4 (20.1) ***p = 0.09(NS)	33.2 (10.8) ***p = NS	NS