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Table 1 Current "Preferred" Regimens for Initial Treatment of HIV Infection in Adults and Adolescents

From: Disease Management - Constructing Optimal NRTI-Based Combinations: Past, Present, and Future

DHHS Recommended Regimens

NNRTI-based

EFV* + (ZDV or TDF) + (3TC or FTC)

PI-based

LPV/r + ZDV + (3TC or FTC)

  1. *Efavirenz is not recommended for use in first trimester pregnancy or in women who want to conceive or are not adhering to an effective contraceptive regimen.
  2. DHHS = US Department of Health and Human Services; PI = protease inhibitor; ZDV = zidovudine; 3TC = lamivudine; FTC = emtricitabine; TDF = tenofovir disoproxil fumarate; NNRTI = nonnucleoside reverse transcriptase inhibitor
  3. Adapted from Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. US Department of Health and Human Services. October 6, 2005