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Figure 3 | Journal of the International AIDS Society

Figure 3

From: Disease Management - Constructing Optimal NRTI-Based Combinations: Past, Present, and Future

Figure 3

Percentage of subjects who had regimen failure with resistance to NRTIs according to Treatment Group. Percentage of subjects who had regimen failure with resistance to PIs according to Treatment Group. For subjects in groups 1 (initial therapy = didanosine/stavudine/efavirenz), 2 (initial therapy = didanosine/stavudine/nelfinavir), 3 (lamivudine/zidovudine/efavirenz), and 4 (lamivudine/zidovudine/nelfinavir), the bars show the cumulative percentage of subjects with drug resistance at the time of the first or second regimen failure; for subjects in groups 5 (initial therapy = didanosine/stavudine/efavirenz/nelfinavir ddI/d4T/EFV/NFV) and 6 lamivudine/zidovudine/efavirenz/nelfinavir), the bars show the percentage of subjects with new drug-resistance mutations after the failure of their first regimen. Drug-resistance mutations were identified through the sequencing of the HIV-1 reverse transcriptase and protease of virus isolated from subjects with virologic failure or toxicity-related failure who had plasma HIV-1 RNA levels of at least 1000 copies/mL. From Shafer RW, Smeaton LM, Robbins GK, et al. Comparison of 4-drug regimens and pairs of sequential 3-drug regimens as initial therapy for HIV-1 infection. N Engl J Med. 2003; 349: 2304-2315, with permission of the publisher, Massachusetts Medical Society.

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