Failure to prescribe pneumocystis prophylaxis is associated with increased mortality, even in the cART era: results from the Treat Asia HIV observational database

Table 1 The effect of PCP prophylaxis on PCP diagnosis (adjusted by CD4 count)

	Number of patients*	PCP diagnosis	Person times (year)	Rate (per 100 person-years)	adjusted IRR**	95% CI	p value
Among all patients without PCP at enrolment (n = 3879)
Receiving PCP prophylaxis
Yes	1567	23	2498.02	0.92	1.00
No	3439	39	9942.69	0.39	0.95	(0.397, 2.255)	0.901
CD4 count (cells/mm ³ )
< = 49	442	20	336.69	5.94	1.00
50~99	513	7	366.91	1.91	0.17	(0.053, 0.551)	0.003
100~199	1352	10	1446.18	0.69	0.06	(0.020, 0.170)	< 0.001
200~299	1856	9	2130.43	0.42	0.02	(0.008, 0.073)	< 0.001
300+	3042	14	8088.58	0.17	0.01	(0.003, 0.024)	< 0.001
Not available	120	2	71.91	2.78	0.16	(0.020, 1.249)	0.080
Among patients without PCP at enrolemnt and with CD4 count < 200 cells/μL (n = 1592)
Receiving PCP prophylaxis
Yes	1109	18	1309.44	1.37	1.00
No	955	19	840.34	2.26	1.39	(0.463, 4.142)	0.560
CD4 count (cells/mm ³ )
< = 49	442	20	336.69	5.94	1.00
50~99	513	7	366.91	1.91	0.18	(0.056, 0.556)	0.003
100~199	1352	10	1446.18	0.69	0.05	(0.016, 0.143)	< 0.001