Figure 5

T cell activation, CD4⁺T cell counts, and HIV-1 plasma viral load in the rural setting. Correlation between activation marker antibody binding capacity (ABC) of peripheral blood T cells and CD4+ T cell counts (panels A, C and E), or HIV-1 plasma viral load levels (panels B, D and F) in 61 treatment-naïve HIV-1 infected patients living in Nouna, rural Burkina Faso. ABC was derived from the median fluorescence intensity as described in the Methods section. Panel A shows the correlation between the ABC of CD4⁺CD95^bright T cells and CD4⁺ T cell counts, and panel B between the ABC of CD4⁺CD95^bright T cells and HIV-1 plasma viral load. Panel C depicts the correlation between the ABC of CD4⁺CD95^dim T cells and CD4⁺ T cell counts, and panel D the correlation between the ABC of CD4⁺CD95^dim T cells and HIV-1 plasma viral load. Panel E shows the correlation between the ABC of CD8⁺CD38⁺ T cells and CD4⁺ T cell counts, and panel F between the ABC of CD8⁺CD38⁺ T cells and HIV-1 plasma viral load. Correlations between variables were explored by calculation of Pearson's correlation coefficient (r) and the coefficient of determination (R²), which are indicated for each analysis.