Skip to main content

Table 3 Follow up CD4% and HIV-1 viral load after detecting major PI

From: It is time to consider third-line options in antiretroviral-experienced paediatric patients?

Patients who continued on an NNRTI regimen

CD4% range (mean CD4%); number (n) of patients

HIV-1 VL range (geometric mean of detectableVL) in IU/ml; number (n) of patients

Baseline*

19.9 - 49.6 (32.2); n = 5

2300-47,000 (15,804); n = 5

First follow up

23.2-39.7 (30.8); n = 5

9400-25,000 (14,397); n = 5

Second follow up

22.9-46.4 (32.4); n = 5

700-38,000 (5504); n = 4

Patients who continued on an LPV/r regimen

  

Baseline*

29.4-39.9 (34.6); n = 5

1000-34,000 (3898); n = 6

First follow up

25.6-36.6 (32.4); n = 5

1 × LDL, remainder 1800-38,000 (7473); n = 6

Second follow up

27.2-40.8 (35.6); n = 5

1 × LDL, remainder 320-390 (355); n = 5

Total: All patients

  

Baseline*

17.1-49.6 (31.9); n = 11

1000-47,000 (6450); n = 12

First follow up

23.2-39.7 (31.4); n = 11

1 × LDL, remainder 1800-38,000

(9558); n = 11

Second follow up

22.9-46.4 (33.1); n = 11

1 × LDL, remainder 320-38,000 (1794); n = 9

  1. VL: Viral load
  2. *Baseline: Refers to values at the time of the first resistance test that resulted in a decision to either continue a PI regimen or switch to an NNRTI regimen
  3. First follow up: Approximately six months after baseline
  4. Second follow up: Approximately 12 months after baseline
  5. LDL: Lower than detection limit (of 357 copies/ml)