Figure 1

HIV latency and infection of resting memory CD4+ T cells. (A) In activated CD4+ T cells the virus life cycle is efficient, with rapid integration, virion production and subsequent death of the infected cells. (B) Latent infection can be established in CD4+ resting memory T cells following incubation with multiple chemokines [36, 37]. (C) Alternatively, latently infected cells may arise following the reversion of an infected activated cell to a resting state [38–40].