Table 4 Multivariable models showing the hazard ratios for the associations between enrolment creatinine clearance and times to overall mortality

Creatinine clearance^b (mL/min)

   ≥60 (reference)

1.0

1.0

   < 60

1.73 (1.19-2.51)^c

1.25 (0.84-1.86)

Age (per 10 year increase)

1.22 (1.02-1.45)^d

1.27 (1.07-1.51)^c

Male sex (compared with female sex)

1.91 (1.29-2.81)^e

2.40 (1.61-3.59)^f

WHO stage 2 (compared with stage 1)

1.54 (1.09-2.18)^c

1.37 (0.97-1.95)

CD4 cell count

(per 50 cells/mm³ increase)

0.96 (0.91-1.01)

0.97 (0.91-1.02)

Haemoglobin (per 1 g/dL increase)

0.76 (0.72-0.81)^f

0.78 (0.73-0.83)^f

Initiation of antiretroviral therapy (compared with no initiation)

1.36 (0.91-2.02)

1.35 (0.90-2.01)

Weight (per 1 kg increase)

0.95 (0.93-0.97)^f