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Table 2 Multivariable models showing the hazard ratios for the associations between enrolment creatinine clearance and times to meeting criteria for initiation of cARTa

From: Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected kenyan adults not initially requiring combination antiretroviral therapy

 

Hazard ratios (95% confidence intervals)

Enrolment characteristic

Model 1

Model 2 b

Creatinine clearancec(mL/min)

  

   ≥60 (reference)

1.0

1.0

   < 60

1.34 (1.23-1.52)d

1.24 (1.11-1.39)d

Age (per 10 year increase)

1.00 (0.95-1.05)

1.01 (0.96-1.07)

Male sex (compared with female sex)

1.22 (1.09-1.37)e

1.27 (1.13-1.42)d

WHO stage 2 (compared with stage 1)

1.34 (1.22-1.48)d

1.30 (1.18-1.43)d

CD4 cell count

(per 50 cells/mm3 increase)

0.88 (0.87-0.90)d

0.88 (0.87-0.90)d

Haemoglobin (per 1 g/dL increase)

0.90 (0.88-0.92)d

0.91 (0.89-0.93)d

Weight (per 1 kg increase)

 

0.99 (0.98-0.99)d

  1. aCombination antiretroviral therapy, defined as development of either CD4 cell count < 200 cells/mm3 or WHO disease stage 3 or 4
  2. bModel 1 adjusted for weight
  3. cEstimated using the Cockcroft-Gault equation
  4. dP < 0.0001
  5. eP < 0.001