Table 1 First- and second-line antiretroviral therapy regimens in use in TREAT Asia and IeDEA Southern Africa
Site | Country | Nationally recommended paediatric first-line ART regimen* | Nationally recommended paediatric second-line ART regimen after NNRTI | Most commonly used second-line regimen in current site cohort |
|---|---|---|---|---|
TREAT Asia | Â | Â | Â | Â |
National Center for HIV, AIDS, Dermatology, and Sexually Transmitted Infections | Cambodia | d4T or AZT+3TC+NVP or EFV If NNRTI exposure: d4T+3TC+LPV/r | ABC+ ddI+LPV/r | ABC+3TC+LPV/r |
Beijing Ditan Hospital | China | d4T or AZT+3TC+NVP or EFV If NNRTI exposure: AZT+3TC+LPV/r | ABC+3TC+AZT+LPV/r | ABC+3TC+AZT+LPV/r |
YRG Centre for AIDS Research and Education | India | d4T or AZT+3TC+NVP or EFV | ABC+ddI+3TC+LPV/r | TDF or ddI+3TC or FTC+LPV/r |
Cipto Mangunkusumo Hospital | Indonesia | d4T or AZT+3TC+NVP or EFV | ddI+3TC+LPV/r | ddI+3TC+LPV/r |
Hospital Kuala Lumpur | Malaysia | <3yr: AZT+3TC or ddI+NVP ≥3yr: AZT+3TC or ddI+EFV | 2 new NRTI+LPV/r | d4T+3TC+LPV/r |
Hospital Likas | Malaysia | <3yr: AZT+3TC or ddI+NVP ≥3yr: AZT+3TC or ddI+EFV | 2 new NRTI+LPV/r | d4T+ddI+LPV/r |
Hospital Penang | Malaysia | <3yr: AZT+3TC or ddI+NVP ≥3yr: AZT+3TC or ddI+EFV | 2 new NRTI+LPV/r | -- |
Hospital Raja Perempuan Zainab | Malaysia | <3yr: AZT+3TC or ddI+NVP ≥3yr: AZT+3TC or ddI+EFV | 2 new NRTI+LPV/r | d4T+ddI+LPV/r |
Chiang Mai University Medical Centre | Thailand | d4T or AZT+3TC+NVP or EFV | ddI+ABC or 3TC+PI/r | AZT+3TC+LPV/r |
Chiang Rai Regional Hospital | Thailand | d4T or AZT+3TC+NVP or EFV | ddI+ABC or 3TC+PI/r | AZT+3TC+LPV/r |
HIV-NAT | Thailand | d4T or AZT+3TC+NVP or EFV | ddI+ABC or 3TC+PI/r | AZT+3TC+LPV/r |
Khon Kaen University Medical Centre | Thailand | d4T or AZT+3TC+NVP or EFV | ddI+ABC or 3TC+PI/r | AZT+ddI+LPV/r |
Siriraj Hospital | Thailand | d4T or AZT+3TC+NVP or EFV | ddI+ABC or 3TC+PI/r | AZT+ddI+LPV/r |
Children's Hospital 1 | Vietnam | d4T+3TC+NVP | ABC+ddI+LPV/r | -- |
Children's Hospital 2 | Vietnam | d4T+3TC+NVP | ABC+ddI+LPV/r | ABC+ddI+LPV/r |
National Hospital of Paediatrics | Vietnam | d4T+3TC+NVP | ABC+ddI+LPV/r | ABC+ddI+LPV/r |
IeDEA Southern Africa | Â | Â | Â | Â |
Lighthouse Clinic | Malawi | d4T+3TC+NVP | ABC+ddI+LPV/r | AZT+3TC+LPV/r |
Paediatric Day Hospital, Maputo | Mozambique | d4T or AZT+3TC+NVP or EFV If NNRTI exposure: d4T or AZT+3TC+LPV/r | ABC+ddI+LPV/r | None |
Rahima Moosa Mother and Child Hospital | South Africa | <3yr/10kg: d4T+3TC+LPV/r >3yr/10kg: d4T+3TC+EFV | AZT+ddI+LPV/r | ABC+3TC+LPV/r |
Gugulethu Community Health Centre | South Africa | <3yr/10kg: d4T+3TC+LPV/r >3yr/10kg: d4T+3TC+EFV | AZT+ddI+LPV/r | AZT+ddI+EFV or LPV/r ABC+3TC+LPV/r |
Harriet Shezi Clinic | South Africa | <3yr/10kg: d4T+3TC+LPV/r >3yr/10kg: d4T+3TC+EFV | AZT+ddI+LPV/r | AZT+ddI+LPV/r |
Khayelitsha Community Health Centre | South Africa | <3yr/10kg: d4T+3TC+LPV/r >3yr/10kg: d4T+3TC+EFV | AZT+ddI+LPV/r | AZT+ddI+LPV/r |
McCord Hospital | South Africa | <3yr/10kg: d4T+3TC+LPV/r >3yr/10kg: d4T+3TC+EFV | AZT+ddI+LPV/r | AZT+ddI+LPV/r |
Red Cross Children's Hospital | South Africa | <3yr/10kg: d4T+3TC+LPV/r >3yr/10kg: d4T+3TC+EFV | AZT+ddI+LPV/r | AZT+ddI+EFV |
Tygerberg Hospital | South Africa | <3yr/10kg: d4T+3TC+LPV/r >3yr/10kg: d4T+3TC+EFV | AZT+ddI+LPV/r | AZT+ddI+LPV/r |
Newlands Clinic | Zimbabwe | AZT+3TC+NVP | ddI+3TC+LPV/r | d4T+3TC+NVP |