Table 1

n (%)

592 (25.50)

856 (36.86)

311 (13.39)

563 (24.25)

-

DEMOGRAPHICS

Women, n (%)

284 (47.9)

245 (28.62)

145 (46.62)

167 (29.66)

< 0.001

Age mean (± S)

43.3 (6.7)

44.4 (6.6)

45.4 (7.7)

46.9 (7.8)

< 0.001

Physical activity, n (%)

232 (39.19)

282 (32.94)

103 (33.12)

152 (27.00)

< 0.001

Smoke (> 10 cigs/day), n (%)

187 (31.59)

285 (33.29)

73 (23.47)

165 (29.31)

0.010

Alcohol consumption, n (%)

270 (45.61)

363 (42.41)

154 (49.52)

279 (49.56)

0.032

ANTHROPOMETRICS

BMI mean (± SD)

21.2 (2.2)

21.7 (2.3)

26.3 (3.9)

27.1 (3.8)

< 0.001

VAT cm³, median (IQR)

75 (49; 103)

100 (67; 138)

136 (101; 194)

172 (125; 236)

< 0.001

Waist Circumference cm, median (IQR)

79 (75; 83)

81 (77; 85)

94 (90; 98)

95 (91; 101)

< 0.001

Hip Circumference cm, median (IQR)

87 (83; 90)

86 (83; 89)

94 (91; 97)

94 (90.5; 98)

< 0.001

Thigh Circumference cm, median (IQR)

45 (42.5; 48)

45 (43; 48)

49 (46; 52)

49 (46; 52)

< 0.001

% of Leg Fat, median (IQR)

12.6 (7.2; 19.9)

7.7 (5.6; 12.7)

18.1 (12.5; 26.2)

14.0 (9.9; 21.1)

< 0.001

HIV history

IDU n (%)

201 (33.95%)

286 (33.41%)

99 (31.83%)

151 (26.82%)

< 0.001

CD4+ Nadir median (IQR)

181 (78; 260)

154 (59; 260)

189 (90; 290)

171.5 (63; 260)

0.014

CD4+ Current median (IQR)

499.5 (370; 672)

523 (364; 700)

492 (360; 658)

543.5 (375; 737)

0.113

VL undetectable n (%)

363 (61.32)

492 (57.48)

190 (61.09)

329 (58.44)

0.432

Months of PI exposure median (IQR)

24 (0; 60)

35.5 (8; 69.5)

30 (0; 58)

39 (9;7269)

0.005

Months of NNRTI exposure median (IQR)

16 (0; 45)

18 (0; 48)

17 (0; 49)

16 (0; 46)

0.445

CARDIOVASCULAR

Framingham risk median (IQR)

2 (1; 5)

6 (2; 10)

2 (1; 6)

6 (2; 12)

< 0.001

Hypertension, n (%)

131 (22.13)

302 (35.28)

119 (38.26)

259 (46.00)

< 0.001

Albuminuria, n (%)

38 (6.42)

84 (9.81)

24 (7.72)

59 (10.48)

< 0.001

LIPID METABOLISM

Triglycerides median (IQR), mmol/L

1.03 (0.81; 1.27)

2.32 (1.87; 3.41)

1.10 (0.89; 1.30)

2.37 (1.85; 3.34)

< 0.001

Total cholesterol mean (± SD), mmol/L

4.43 (1.09)

5.05 (1.22)

4.55 (1.10)

5.17 (1.30)

< 0.001

HDL mean (± SD), mmol/L

1.36 (0.44)

1.05 (0.42)

1.33 (0.41)

1.06 (0.30)

< 0.001

LDL mean (± SD), mmol/L

2.70 (0.84)

3.02 (1.03)

2.83 (0.91)

3.09 (1.01)

< 0.001

ApoA1 mean (± SD), mg/dL

148.7 (32.6)

137.5 (26.8)

149.9 (29.8)

139.7 (27.0)

< 0.001

ApoB mean (± SD), mg/dL

85.6 (23.4)

108.8 (29.0)

90.3 (24.3)

110.3 (27.3)

< 0.001

HOMA-IR median (IQR)

2.25 (1.39; 3.38)

3.07 (2.04; 5.01)

3.26 (2.21; 5.13)

4.31 (2.74; 6.68)

< 0.001