A comparison of the FDA TLOVR and FDA Snapshot algorithms based on studies evaluating once-daily vs. twice daily lopinavir/ritonavir (LPV/r) regimens

Table 1 Percent of subjects with HIV-1 RNA <50 copies/mL using FDA TLOVR and Snapshot algorithms

Week	Analysis Algorithm	Study 418	Study 418	Study 730	Study 730	Study 802	Study 802
		QD (n=115)	BID (n=75)	QD (n=333)	BID (n=331)	QD (n=300)	BID (n=299)
48	TLOVR	71%	65%	78%	77%	55%	52%
48	Snapshot	70%	64%	80%	78%	57%	54%
96	TLOVR	57%	55%	63%	64%	n/a	n/a
96	Snapshot	57%	55%	65%	69%	n/a	n/a

n/a not available, 48-week study
P>0.05 for all QD vs. BID comparisons within each study, analysis algorithm, and timepoint