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Table 1

From: Once-daily S/GSK1349572 combination therapy in antiretroviral-naïve adults: rapid and potent 24-week antiviral responses in SPRING-1 (ING112276)

Planned Week 24 Interim Analysis Results

S/GSK1349572 10 mg (n=53)

S/GSK1349572 25mg (n=51)

S/GSK1349572 50mg (n=51)

EFV control (n=50)

Mean baseline HIV-1 RNA (log10 c/mL)

4.42

4.38

4.58

4.46

%<50c/mL at 24 wks (by TLOVR)

96% (51/53)

90% (46/51)

92% (47/51)

78% (39/50)

Median baseline (change from baseline at 24 weeks) CD4+ cells/mm3

289 (+159)

330 (+206)

305 (+167)

308 (+110)†

  1. †p=0.008; Wilcoxon two-sample test vs. S/GSK1349572 arms (median change: +176)