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Table 2 Family-centred PMTCT intervention models: Extension of ART services

From: Family-centred approaches to the prevention of mother to child transmission of HIV

Citation, country, sample size Design Target group Family-centred PMTCT programme components Outcomes Study limitations
[24] Byakika Tusiime et al, 2009; Uganda; 177 individuals Prospective cohort Families At one MTCT-Plus Initiative site in Uganda, treatment and therapy for mothers and HIV-infected family members was provided, including basic treatment of HIV-related opportunistic infections, as well as provision of antiretroviral therapy (ART) In this family-centred model, near perfect adherence to ART was observed: mean adherence in studied groups ranged from 87.7% to 100%
Among adults, depression was significantly associated with incomplete adherence (p = 0.04; OR = 0.32; 95% CI 0.11-0.93)
Information was not collected on the time gap between delivery and initiation of therapeutic treatment
[25] Tonwe-Gold et al, 2009; Côte d'Ivoire; 605 women and 582 infants Prospective cohort Families Through the MTCT-Plus Initiative, HIV prevention and care for family members, including clinical ART services
Involvement and support of partners and children
Among cohort of 568 women with a living spouse, 53% disclosed HIV status to their male partner Enrolment of HIV-positive male partners was low (12%)
Retention of individuals on ART was high (2.5% index women, 5.5% index partners lost to follow up)
Non-disclosure rates to partners remained high, even in the context of ART access
Limited access to children outside the ANC context