Skip to main content

Table 2 Factors associated with death and loss to follow up (LTFU) after 24 months of ART (n = 2291)a,b

From: Increased vulnerability of rural children on antiretroviral therapy attending public health facilities in South Africa: a retrospective cohort study

Patient factor

HR (95% CI) of death

HR (95% CI) of LTFU

 

Univariate

Adjusted

Univariate

Adjusted

Male gender

0.86 (0.54-1.38)

0.83 (0.51-1.34)

1.06 (0.79-1.42)

1.1 (0.82-3.12)

Age

    

>2 years

1

1

1

1

1-2 years

1.75 (0.89-3.46)

1.50 (0.74-2.98)

1.69 (1.11-2.57)

1.61 (0.96-2.68)

<1 year

3.72 (1.88-7.35)

2.73 (1.32-5.53)

1.87 (1.06-3.31)

1.81 (0.94-3.64)

Severe clinical status

    

No

1

1

1

1

Yes

5.34 (3.07-9.43)

4.50 (2.52-8.00)

1.74 (1.23-2.46)

1.47 (1.03-2.12)

Not available

5.10 (2.62-9.93)

5.03 (2.37-10.68)

2.37 (1.62-3.50)

1.63 (1.02-2.59)

    Immunodeficiency

    

Not severe

1

1

1

1

Severe

8.71 (2.11-35.8)

6.77 (1.63-28.1)

0.85 (0.57-1.29)

0.81 (0.52-1.24)

Not available

8.80 (2.06-37.7)

4.74 (1.08-20.7)

1.68 (1.10-2.56)

1.18 (0.74-1.87)

Tuberculosis at ART start

    

No

1

1

1

1

Yes

2.88 (1.24-6.67)

2.71 (1.15-6.34)

1.49 (0.73-3.02)

1.41 (0.69-2.86)

    Initial ART regimen

    

Non PI-based

1

1

1

1

PI-based

1.37 (0.80-2.37)

1.45 (0.72-2.96)

1.42 (1.02-1.98)

1.34 (0.88-2.04)

Non d4t-based

1

1

1

1

d4T-based

0.91 (0.33-2.52)

0.87 (0.32-2.54)

0.80 (0.46-1.42)

0.79 (0.44-1.44)

Urban/rural classification

    

Urban

1

1

1.67 (0.89-3.19)

1.14 (0.57-2.24)

Rural

2.39 (1.31-4.36)

2.41 (1.25-4.67)

1

1

Rural/urban

1.17 (0.60-2.26)

1.02 (0.51-2.10)

2.38 (1.36-5.39)

2.85 (1.41-5.79)

  1. aAdjusted hazard ratios are adjusted for all variables displayed in the table
  2. b41 (1.7%) of children were excluded due to missing baseline tuberculosis treatment information