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Table 3 Factors associated with negative physical health summary score at week 48

From: Quality of life and the impact of drug toxicities in a South African community-based antiretroviral programme

Variable

 

Univariate model

Multivariate model 1

Multivariate model 2

  

Odds ratio, 95% CI

(P-value)

Odds ratio, 95% CI

(P-value)

Odds ratio, 95% CI

(P-value)

Age (continuous)

 

1.04, (0.98; 1.09)

0.184

1.08, (1.01; 1.15)

0.034

1.07 (1.01; 1.14)

0.029

Age

(≤ 34 = 0, >34 = 1)

 

1.20, (0.56; 2.60)

0.637

  

Gender

(male = 0, female = 1)

 

0.55, (0.19; 1.56)

0.260

0.52, (0.14; 1.99)

0.341

 

WHO stage

(1&2 = 0, 3&4 = 1)

 

0.38, (0.13; 1.08)

0.068

0.61, (0.17; 2.15)

0.441

 

Baseline CD4 count cells/mm3

(>50 = 0, ≤ 50 = 1)

 

0.42, (0.15; 1.17)

0.098

0.93, (0.25; 3.41)

0.910

 

Baseline viral load log copies/ml

(≤ 5 = 0, >5 = 1)

 

0.24, (0.10; 0.59)

0.002

0.48, (0.14; 1.65)

0.245

0.22, (0.08; 0.60)

0.003

Pre-HAART PHS score

(continuous)

 

1.14 (1.07; 1.21)

<0.001

1.16 (1.08; 1.24)

<0.001

1.15 (1.08; 1.23)

<0.001

Week 48 CD4 count cells/mm3

(<250 = 0, ≥ 250 = 1)

 

0.63, (0.29; 1.37)

0.245

  

Week 48 CD4 count cells/mm3

<200

1

  
 

200–350

0.62, (0.25; 1.51)

0.29

  
 

350–500

0.67, (0.22; 2.07)

0.483

  
 

≥ 500

0.42, (0.08; 2.21)

0.309

  

Week 48 viral load copies/ml

(<50 = 0, ≥ 50 = 1)

 

0.96, (0.37; 2.48)

0.935

  

Week 48 viral load copies/ml

<50

1

  
 

50–399

0.39, (0.08; 1.79)

0.224

  
 

400–4999

1.10, (0.11; 11.00)

0.936

  
 

≥ 5000

3.30, (0.77; 14.07)

0.107

  

Week 48 log viral load

log copies/ml

(<1.69 = 0, ≥ 1.69 = 1)

 

0.96, (0.37; 2.48)

0.935

  

Week 48 log viral load

log copies/ml

<1.69

1

  
 

1.69–2.59

0.58, (0.16; 2.14)

0.414

  
 

2.60–3.69

1.10, (0.11; 11.00)

0.936

  
 

≥ 3.69

2.47, (0.51; 11.74)

0.225

  

Δ CD4 count cells/mm3

 

0.995, (0.991; 0.999)

0.010

0.998, (0.993; 1.003)

0.420

 

Δ log viral load log copies/ml

 

0.58, (0.37; 0.90)

0.015

0.66, (0.36; 1.27)

0.209

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