Table 1 Baseline characteristics of 7536 individuals enrolled in Themba Lethu Clinical Cohort (TLCC) by gender and pregnancy status
| Â | Female, pregnant (n = 574) | Female, non-pregnant (n = 4437) | Male (n = 2525) | p value (non-pregnant female vs. male) |
|---|---|---|---|---|
Age (Median and IQR) | 34.0 (29.4-40.2) | 34.9 (30.1-41.2) | 37.2 (32.8-43.3) | < 0.0001 †|
Ethnicity | Â | Â | Â | 0.5818 |
   African or black | 560 (97.6) | 4253 (95.9) | 2375 (94.1) |  |
   Coloured | 14 (2.4) | 153 (3.5) | 97 (3.8) |  |
   Asian, White, or Missing | 0 (0.0) | 31 (0.7) | 53 (2.1) |  |
Employment | Â | Â | Â | < 0.0001 |
   Employed, student, retired | 195 (34.0) | 1455 (32.8) | 1086 (43.0) |  |
   Unemployed | 354 (61.7) | 2619 (59.0) | 1262 (50.0) |  |
   Unknown or missing | 25 (4.4) | 363 (8.2) | 177 (7.0) |  |
BMI | Â | Â | Â | < 0.0001 |
   < 18.5 | 7 (1.2) | 786 (17.7) | 639 (25.3) |  |
   18.5-24.9 | 208 (36.2) | 2369 (53.4) | 1538 (60.9) |  |
   25-29.9 | 230 (40.1) | 829 (18.7) | 279 (11.1) |  |
   ≥ 30 | 128 (22.3) | 421 (9.5) | 54 (2.1) |  |
   Missing | 1 (0.2) | 32 (0.7) | 15 (0.6) |  |
Hemoglobin* | Â | Â | Â | 0.7088 |
   Normal | 399 (69.5) | 2095 (47.2) | 1202 (47.6) |  |
   Low | 163 (28.4) | 2298 (51.8) | 1294 (51.3) |  |
   Missing | 12 (2.1) | 44 (1.0) | 29 (1.2) |  |
WHO stage | Â | Â | Â | 0.0003 |
   I | 427 (74.4) | 1944 (43.8) | 1011 (40.0) |  |
   II | 64 (11.2) | 566 (12.8) | 286 (11.3) |  |
   III | 74 (12.9) | 1482 (33.4) | 927 (36.7) |  |
   IV | 9 (1.6) | 445 (10.0) | 301 (11.9) |  |
CD4 count | Â | Â | Â | Â |
   Median (IQR) | 146 (91-192) | 86 (32-157) | 75 (23-146) | < 0.0025 †|
   Mean (95% CI) | 145 (138-152) | 111 (107-114) | 98 (94-102) | < 0.0001 ‡ |
   ≤ 50 | 53 (9.2) | 1370 (30.9) | 950 (37.6) | < 0.0001 |
   51-99 | 91 (15.9) | 885 (20.0) | 453 (17.9) |  |
   100 - 199 | 249 (43.4) | 1319 (29.7) | 703 (27.8) |  |
   200 - 349 | 91 (15.9) | 366 (8.3) | 169 (6.7) |  |
   ≥ 350 | 6 (1.1) | 129 (2.9) | 61 (2.4) |  |
   Missing | 84 (14.6) | 368 (8.3) | 189 (7.5) |  |
Initial HAART regimen | Â | Â | Â | < 0.0001 |
   d4T-3TC-EFV | 54 (9.4) | 3622 (81.6) | 2211 (87.6) |  |
   d4T-3TC-NVP | 33 (5.8) | 436 (9.8) | 117 (4.6) |  |
   d4T-3TC-LPVr | 482 (84.0) | 112 (2.5) | 24 (1.0) |  |
   Other | 5 (0.9) | 267 (6.0) | 173 (6.9) |  |