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Table 3 Novel approaches to the design of envelope immunogens

From: Sang Froid in a time of trouble: is a vaccine against HIV possible?

Mimic native trimer on virion surface

Redirect immune responses to conserved conformational epitopes

   Add disulfides or other amino acids to stabilize conformational epitopes

   Bind envelope to CD4 or CD4-mimetic peptide

   Remove carbohydrate residue or entire carbohydrate side chains

Redirect responses away from variable epitopes

   Remove one or more variable loops

   Add carbohydrate side chains to hide

   variable regions