From: Sang Froid in a time of trouble: is a vaccine against HIV possible?
Mimic native trimer on virion surface |
Redirect immune responses to conserved conformational epitopes |
   Add disulfides or other amino acids to stabilize conformational epitopes |
   Bind envelope to CD4 or CD4-mimetic peptide |
   Remove carbohydrate residue or entire carbohydrate side chains |
Redirect responses away from variable epitopes |
   Remove one or more variable loops |
   Add carbohydrate side chains to hide |
   variable regions |