Sang Froid in a time of trouble: is a vaccine against HIV possible?

Table 2 Similarities between Hepatitis C and HIV

	HCV	HIV
Envelope and Core Ags	+	+
Glycosylated envelope protein	+	+
Envelope is neut. target, but hypervariable	+	+
Chronic viremia	+	+
Escape mutation	+	+
Geographical genetic variation	+	+
PD-1 Upregulated	+	+
High titer neutralizing Ab protects	+	+
Strong cell responses against multiple epitopes necessary for control of viremia	+	+
CD4+ cells needed to sustain CD8+ T cells	+	+
Tcm cells needed for long-term control	+	+