Table 1
From: Simplification from TPV/RTV 500/200 BID to TPV/RTV 500/100 BID guided by therapeutic drug monitoring
Pts. | Concomitant ARV | Major mutations | HCV | Baseline (TPV500/RTV200) | Week 12 (TPV500/RTV100) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TPV Ctrough | AST | ALT | Cholesterol | Triglycerides | TPV Ctrough | Therapeutic Levels | AST | ALT | Cholesterol | Triglycerides | ||||
1 | ABC 3TC AZT | 10 V, 47 V, 54 V | Yes | 45,4 | 83 | 140 | 179 | 134 | ↓ 17% | Yes | ↓ 45% | ↓ 49% | ↓ 9% | ↓ 7% |
2 | TDF FTC RAL | 84 V | No | 37,5 | 20 | 16 | 261 | 127 | ↓ 30% | No | ↑ 50% | 0% | ↓ 13% | ↑ 25% |
3 | TDF FTC RAL | No data | No | 24,9 | 20 | 27 | 194 | 104 | ↓ 18% | No | ↓ 5% | ↓ 15% | 0% | ↑ 123% |
4 | TDF FTC | None | No | 29,6 | 37 | 73 | 245 | 384 | ↓ 14% | Yes | ↓ 19% | ↓ 49% | ↓ 22% | ↓ 61% |
5 | ABC 3TC AZT | None | No | 22,8 | 24 | 29 | 205 | 229 | ↓ 9% | No | ↓ 33% | ↓ 35% | ↓ 2% | ↑ 40% |