Table 1
|  |  | Arithmetic Mean ± SD |  | Relative Bioavailability |  |
|---|---|---|---|---|---|
| Â | Pharmacokinetic Parameter | Test (Meal) | Reference (Fasting) | Point Estimate # | 90% CI |
|  | Ritonavir Dosed Under Moderate Fat Meal Condition (20–30% Fat, N = 26) |  |  |  |  |
Moderate Fat vs. Fasting | Cmax (mg/mL) | 0.47 ± 0.27 | 0.60 ± 0.31 | 0.784 | 0.675 – 0.910 |
|  | Tmax (h) | 4.2 ± 1.2 | 3.2 ± 1.2 |  |  |
|  | AUCt (mg*h/mL) | 3.8 ± 2.0 | 4.6 ± 2.0 | 0.791 | 0.719 – 0.870 |
|  | AUCinf (mg*h/mL) | 3.9 ± 2.1 | 4.7 ± 2.0 | 0.798 | 0.726 – 0.877 |
| Â | Ritonavir Dosed Under High Fat Meal Condition (50% Fat, N = 25) | Â | Â | Â | Â |
High Fat vs. Fasting | Cmax (mg/mL) | 0.44 ± 0.21 | 0.60 ± 0.31 | 0.765 | 0.657 – 0.892 |
|  | Tmax (h) | 4.8 ± 1.1 | 3.2 ± 1.2 |  |  |
|  | AUCt (mg*h/mL) | 3.5 ± 1.6 | 4.6 ± 2.0 | 0.763 | 0.692 – 0.841 |
|  | AUCinf (mg*h/mL) | 3.6 ± 1.7 | 4.7 ± 2.0 | 0.773 | 0.702 – 0.851 |