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Table 1

From: The effect of food on ritonavir bioavailability following administration of ritonavir 100 mg film-coated tablet in healthy adult subjects

   Arithmetic Mean ± SD   Relative Bioavailability  
  Pharmacokinetic Parameter Test (Meal) Reference (Fasting) Point Estimate # 90% CI
  Ritonavir Dosed Under Moderate Fat Meal Condition (20–30% Fat, N = 26)     
Moderate Fat vs. Fasting Cmax (mg/mL) 0.47 ± 0.27 0.60 ± 0.31 0.784 0.675 – 0.910
  Tmax (h) 4.2 ± 1.2 3.2 ± 1.2   
  AUCt (mg*h/mL) 3.8 ± 2.0 4.6 ± 2.0 0.791 0.719 – 0.870
  AUCinf (mg*h/mL) 3.9 ± 2.1 4.7 ± 2.0 0.798 0.726 – 0.877
  Ritonavir Dosed Under High Fat Meal Condition (50% Fat, N = 25)     
High Fat vs. Fasting Cmax (mg/mL) 0.44 ± 0.21 0.60 ± 0.31 0.765 0.657 – 0.892
  Tmax (h) 4.8 ± 1.1 3.2 ± 1.2   
  AUCt (mg*h/mL) 3.5 ± 1.6 4.6 ± 2.0 0.763 0.692 – 0.841
  AUCinf (mg*h/mL) 3.6 ± 1.7 4.7 ± 2.0 0.773 0.702 – 0.851
  1. #Antilogarithm of the difference (test minus reference) of the least square means for logarithms.