| | |
Arithmetic Mean ± SD
| |
Relative Bioavailability
| |
|---|
| |
Pharmacokinetic Parameter
|
Test (Meal)
|
Reference (Fasting)
|
Point Estimate #
|
90% CI
|
|---|
| |
Ritonavir Dosed Under Moderate Fat Meal Condition (20–30% Fat, N = 26)
| | | | |
|
Moderate Fat vs. Fasting
|
Cmax (mg/mL)
|
0.47 ± 0.27
|
0.60 ± 0.31
|
0.784
|
0.675 – 0.910
|
| |
Tmax (h)
|
4.2 ± 1.2
|
3.2 ± 1.2
| | |
| |
AUCt (mg*h/mL)
|
3.8 ± 2.0
|
4.6 ± 2.0
|
0.791
|
0.719 – 0.870
|
| |
AUCinf (mg*h/mL)
|
3.9 ± 2.1
|
4.7 ± 2.0
|
0.798
|
0.726 – 0.877
|
| |
Ritonavir Dosed Under High Fat Meal Condition (50% Fat, N = 25)
| | | | |
|
High Fat vs. Fasting
|
Cmax (mg/mL)
|
0.44 ± 0.21
|
0.60 ± 0.31
|
0.765
|
0.657 – 0.892
|
| |
Tmax (h)
|
4.8 ± 1.1
|
3.2 ± 1.2
| | |
| |
AUCt (mg*h/mL)
|
3.5 ± 1.6
|
4.6 ± 2.0
|
0.763
|
0.692 – 0.841
|
| |
AUCinf (mg*h/mL)
|
3.6 ± 1.7
|
4.7 ± 2.0
|
0.773
|
0.702 – 0.851
|
- #Antilogarithm of the difference (test minus reference) of the least square means for logarithms.
