From: Modelling the change in lopinavir apparent oral clearance over time following cessation of lopinavir/ritonavir: data from the TAIL study
Parameter
Estimate
Standard Error
CL0 (L/h)
53.2
8.09
Ki (mg/L)
0.0442
0.0102
V/F (L)
124
8.90
IIV CL0 (%)
16.2
9.69
IIV V/F
12.8
8.67
Residual error – proportional (%)
28.8
12.6
Residual error – additive (mg/L)
0.0117
0.00849