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Table 1

From: Raltegravir: a potent and safe integrase inhibitor with a favourable impact on cardiovascular and liver profile

 

Baseline

3 months

6 months

9 months

12 months

SALVAGE THERAPY

n = 62

n = 39

n = 27

n = 21

n = 9

ΔpHIV-RNA log10 cop/mL

0

-1.8 (-2.6 – -1.2)

-2.1 (-2.7 – -1.3)

-2 (-2.6 – -1.2)

-2.4 (-2.7 – -1.3)

%pts pHIV-RNA<50 cop/mL

0

84

85

86

67

ΔCD4+ cells/μL

0

62 (0–118)

38 (4–61)

82 (20–148)

88 (28–184)

NO SALVAGE THERAPY

n = 44

n = 20

n = 10

n = 4

-

%pts pHIV-RNA<50 cop/mL

100

100

100

100

-

ΔCD4+ cells/μL

0

27 (-8 – +70)

45 (-3 – +98)

13 (-38 – +202)

-

ALL PATIENTS

n = 106

n = 59

n = 37

n = 25

n = 9

Hb g/dL

14.9 (13.7–15.9)

14.9 (13.8 – 16.5)

15.3 (14.2–16.3)

15.4 (14.8–16.4)

14.8 (13.2–16.3)

Glucose mg/dL

98 (92–110)

99 (91–108)

99 (91–104)

99 (92–106)

98 (91–107)

Creatinine mg/dL

0.9 (0.8–1)

0.9 (0.8–1)

0.9 (0.8–1)

0.9 (0.9–1)

0.9 (0.8–1)

AST IU/L

32 (24–50)

29 (25–41)

28 (22–51)

27 (23–34)

31 (22–43)

ALT IU/L

31 (21–62)

32 (23–46)

27 (20–61)

27 (18–39)

28 (21–68)

Total bilirubin mg/dL

0.8 (0.6–1.3)

0.7 (0.6–1)

0.8 (0.6–1.2)

0.8 (0.6–0.9)

0.8 (0.6–0.9)

Total cholesterol mg/dL

185 (147–208)

190 (160–224)

190 (171–217)

201 (176–224)

193 (154–222)

HDL cholesterol mg/dL

33 (26–43)

39 (31–47)*

38 (31–48)

36 (30–44)

33 (28–42)

LDL cholesterol mg/dL

119 (86–132)

124 (84–146)

124 (106–147)

134 (112–147)

137 (104–157)

Triglycerides mg/dL

120 (71–198)

122 (91–163)

136 (69–175)

137 (102–208)

120 (63–143)

  1. All values are expressed as median (IQR), unless otherwise indicated. *p < 0.05 compared to baseline.